Can dalbavancin be used as a catheter lock solution?

Journal of Medical Microbiology
Cristina Díaz-RuízMaría Guembe

Abstract

Purpose. The new lipoglycopeptide dalbavancin has only been approved for acute bacterial skin and skin structure infections. However, its alternative use as a catheter lock solution could facilitate the conservative management of catheter-related bloodstream infection. Our objective was to assess the stability and activity of dalbavancin alone and in combination with heparin against methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant Staphylococcus epidermidis (MRSE) biofilms. We also compared the results with those obtained with vancomycin alone and in combination with heparin.Methodology. We used a 96-well plate in vitro model based on 24 h biofilms of MRSA and MRSE (ATCC 43300, ATCC 35984 and one clinical strain of each). The biofilms were exposed to dalbavancin (0.128 mg ml-1) and vancomycin (5 mg ml-1) alone and in combination with heparin (60 IU). The median percentage reductions in metabolic activity, biomass, bacterial load, and cell viability for each solution were compared.Results. Dalbavancin combined with heparin significantly reduced the median [interquartile range (IQR)] percentage of metabolic activity in MRSA biofilms compared with vancomycin [90.0 % (70.4-92.9 %) versus 35.0 % (14.8-59....Continue Reading

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Citations

Oct 21, 2019·Annals of Clinical Microbiology and Antimicrobials·Carmen Hidalgo-TenorioJuan Pasquau
Sep 30, 2020·Antimicrobial Agents and Chemotherapy·Marta RubiaMaría Guembe
Nov 17, 2019·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GiannellaP Viale
Jan 17, 2022·Infectious Diseases and Therapy·Marta Díaz-NavarroMaría Guembe

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