Can dedicated breast PET help to reduce overdiagnosis and overtreatment by differentiating between indolent and potentially aggressive ductal carcinoma in situ?

European Radiology
Lucía Graña-LópezManuel Vázquez-Caruncho

Abstract

To analyze the utility of metabolic imaging, and specifically of dedicated breast positron emission tomography (dbPET) to differentiate between indolent and potentially aggressive ductal carcinoma in situ (DCIS). After institutional review board approval, we retrospectively reviewed the cases of pure DCIS who underwent dbPET before biopsy and surgery in Lucus Augusti Universitary Hospital (Lugo, Spain) and in Fudan Cancer Institute (Shanghai, China) between January 2016 and May 2018. Grade 1 and "non-comedo" grade 2 DCIS were considered low-risk disease, while intermediate-grade with necrosis or grade 3 cases were included in the high-risk group. DbPET sensitivity and specificity to differentiate between indolent and potentially aggressive DCIS were determined along with their respective 95% confidence intervals. We enrolled 139 surgery-confirmed pure DCIS cases. Fifty were high-risk neoplasms and 89 low-risk DCIS. Only seven low-risk lesions were positive at dbPET and five of potentially aggressive neoplasms did not show FDG uptake, all included into the field of view (FOV). Sensitivity and specificity of dbPET to differentiate between indolent and potentially aggressive DCIS were 90% (95% CI, 77-96%) and 92% (95% CI, 84-97%),...Continue Reading

References

Dec 1, 1992·Archives of Surgery·B A WardT S Ravikumar
Jul 16, 1990·Biochemical and Biophysical Research Communications·T YamamotoH Imura
Feb 16, 2000·Lancet·P C Gøtzsche, O Olsen
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N AvrilM Schwaiger
Jan 11, 2005·The Journal of Pathology·Peter T SimpsonSunil R Lakhani
Dec 6, 2005·Pathology, Research and Practice·Jorge S Reis-FilhoSunil R Lakhani
Jul 20, 2006·The Kaohsiung Journal of Medical Sciences·Shou-Jen KuoDar-Ren Chen
Apr 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Anne Vincent-SalomonUNKNOWN breast cancer study group of the Institut Curie
Nov 1, 2008·Radiation Medicine·Asako AzumaToshihiro O'uchi
Oct 20, 2009·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Hossein JadvarSanjiv S Gambhir
Apr 30, 2010·Journal of the National Cancer Institute·Karla KerlikowskeThea D Tlsty
May 27, 2010·Histopathology·Maria A Lopez-GarciaJorge S Reis-Filho
Sep 28, 2010·European Journal of Nuclear Medicine and Molecular Imaging·Kathy SchillingLarraine Chrystal
Oct 1, 2011·Clinical Oncology : a Journal of the Royal College of Radiologists·K HanE Rakovitch
Dec 17, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Melinda E SandersWilliam D Dupont
May 31, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Lotte E ElshofJelle Wesseling
Aug 25, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Adele FrancisDaniel Rea
Sep 1, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E SenkusUNKNOWN ESMO Guidelines Committee
Sep 15, 2015·Clinical Imaging·Habib RahbarSavannah C Partridge
Feb 18, 2016·Breast Cancer Research : BCR·Christos PetridisElinor J Sawyer
Jun 18, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Ye Young SeoHyung Sun Sohn
Jan 10, 2018·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 15, 2018·Annals of Surgical Treatment and Research·Sungchul KimHayong Yum
Jul 18, 2018·AJR. American Journal of Roentgenology·Gitanjali V PatelRichard Ha
Aug 10, 2018·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Naohiro TairaNaoki Yoshimi
Nov 7, 2018·European Journal of Radiology·L Graña-LópezM Vázquez-Caruncho

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Citations

Aug 5, 2020·European Radiology·Noam NissanLiran Domachevsky
Jan 11, 2021·European Journal of Radiology·Pascal A T Baltzer

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