PMID: 9556468Dec 16, 1998Paper

Can degenerative aortic valve stenosis be related to persistent Chlamydia pneumoniae infection?

Annals of Internal Medicine
J JuvonenP Saikku

Abstract

The cause of age-related degenerative (tricuspid) aortic valve calcification is largely unknown, but one typical characteristic is an active inflammatory process. The presence of Chlamydia pneumoniae in aortic valve stenosis was recently shown. To test the hypothesis that if persistent C. pneumoniae infection plays an active role in the development of aortic stenosis, the organism can be detected in the healthy aortic valves of young persons. A cadaver study. Oulu University Hospital, Oulu, Finland. 46 consecutive cadavers undergoing autopsy. Macroscopic and histologic pathology of aortic valves was determined. The presence of C. pneumoniae was determined by immunohistochemistry. 34 of 46 valves were macroscopically normal. Early lesions of aortic valve disease were found in 12 valves (no lesions in valves from persons 20 to 40 years of age [n = 15], 4 lesions in valves from persons 41 to 60 years of age [n = 16], and 8 lesions in valves from persons older than 60 years of age [n = 15]; P = 0.004). Fifteen of 34 normal valves (44%) and 10 of 12 valves with early lesions (83%) had positive results on staining for C. pneumoniae (P = 0.02). In persons older than 60 years of age, the chance of an early lesion was higher if the valv...Continue Reading

Citations

Jun 1, 2005·International Journal of Cardiology·Humberto PierriMauricio Wajngarten
Feb 5, 2004·The Annals of Thoracic Surgery·David J CohenBarbara D Boyan
Oct 5, 2001·Journal of the American College of Cardiology·A GalanteC Favalli
Nov 7, 1999·Journal of the American College of Cardiology·Y K WongM E Ward
Apr 20, 2002·Current Opinion in Infectious Diseases·Michael Dunne
Jan 23, 1999·Current Opinion in Rheumatology·T JuvonenM J Savolainen
Sep 22, 2007·Current Opinion in Lipidology·Satu HelskePetri T Kovanen
Apr 24, 2009·International Journal of Cardiology·Ertan Yetkin, Johannes Waltenberger
Feb 28, 2009·International Journal of Cardiology·Marie EdvinssonChristina Nyström-Rosander
Nov 24, 1999·The American Journal of Cardiology·R C BahlerM Youssefi
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Nov 4, 2000·Expert Opinion on Investigational Drugs·L Davydov, J W Cheng
Jan 23, 1999·Current Opinion in Rheumatology·E W St Clair, R M McCallum
Mar 11, 2003·Scandinavian Cardiovascular Journal : SCJ·Tatu JuvonenJukka Juvonen

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