Can diet-induced weight loss improve iron homoeostasis in patients with obesity: A systematic review and meta-analysis.

Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
I-Chun TengJung-Su Chang

Abstract

Despite the increasing worldwide prevalence of obesity and iron deficiency (ID), there are still no guidelines on how to treat and manage obesity-related ID. The aim of this systematic review and meta-analysis was to investigate whether weight loss can re-establish iron homoeostasis among subjects with unhealthy weight (overweight [OW] or obesity). PubMed, Medline, Embase, Web of Science, and the Cochrane Library were systemically searched for studies that compared the iron status before and after a weight-loss intervention. A random-effects model was used to calculate the pooled and subgroup weighted mean differences (WMDs) of iron biomarkers. In total, 879 subjects were pooled across 14 studies. Improved haemoglobin was found in longitudinal studies (WMD = 2.50 g/dl, 95% confidence interval [CI]: 0.88, 4.12 g/dl, I2 = 14%) but not in randomized controlled trials or after being stratified by dietary programmes. Significantly increased transferrin saturation was observed in pooled (WMD = 1.68%, 95% CI: 0.97%, 2.39%, I2 = 44%) and subgroup analyses. A meta-regression showed that changes in the iron status were positively correlated with changes in the body mass index (BMI) and the intervention duration but negatively correlated ...Continue Reading

References

Jul 1, 1997·The American Journal of Clinical Nutrition·J BeardF J Peterson
Jul 31, 1998·European Journal of Clinical Nutrition·M J KretschH L Johnson
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Mar 11, 2005·The New England Journal of Medicine·Guenter Weiss, Lawrence T Goodnough
Apr 23, 2008·International Journal of Obesity : Journal of the International Association for the Study of Obesity·M B ZimmermannR F Hurrell
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Sep 30, 2009·Seminars in Hematology·Tomas Ganz, Elizabeta Nemeth
Sep 30, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A AmatoE Miraglia del Giudice
Jul 2, 2011·Journal of Hepatology·Paola DongiovanniLuca Valenti
Sep 5, 2012·International Journal of Obesity : Journal of the International Association for the Study of Obesity·J BaumgartnerM B Zimmermann
Jul 30, 2014·Hematology/oncology Clinics of North America·Elizabeta Nemeth, Tomas Ganz
Sep 13, 2014·Nutrients·Elmar AignerChristian Datz
Apr 7, 2015·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·V GuglielmiP Sbraccia
Aug 11, 2015·European Journal of Haematology·Jeremy J Pratt, Khalid S Khan
Sep 8, 2015·Contemporary Clinical Trials·Rebecca DerSimonian, Nan Laird
Sep 24, 2015·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·L ZhaoF Wang
Sep 27, 2015·American Journal of Hematology·Michael Auerbach, John W Adamson
Oct 18, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·José María Moreno-NavarreteJosé Manuel Fernández-Real
Dec 14, 2016·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Daigo KameiTakashi Akiba
May 11, 2018·International Journal of Chronic Diseases·Axel DignassJürgen Stein
Nov 8, 2018·Blood·Clara Camaschella
Oct 31, 2019·Journal of Internal Medicine·M D CappelliniA T Taher
Jan 31, 2020·JCI Insight·Nathan C WinnAlyssa H Hasty

❮ Previous
Next ❯

Citations

May 1, 2021·Biomolecules·Geir BjørklundDaniel-Ovidiu Costea
Oct 2, 2021·Experimental and Therapeutic Medicine·Naseem Mohammad AlshwaiyatHamid Ali Nagi Al-Jamal

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Rheumatology
Joshua F Baker, Andrew J Ghio
Obesity Reviews : an Official Journal of the International Association for the Study of Obesity
L ZhaoF Wang
Journal of Clinical Pathology
Manuel MuñozAngel Francisco Remacha
© 2021 Meta ULC. All rights reserved