Can digital rectal examination or transrectal ultrasonography biopsy findings predict the side of nodal metastasis in prostate cancer?

Urologic Oncology
Philippe E SpiessLouis L Pisters

Abstract

To assess the use of several preoperative parameters in predicting the side of pelvic lymph node metastasis in patients with prostate cancer. A retrospective chart review (January 1982 to February 2004) identified 106 men with pathology proven lymph node positive prostate cancer for whom complete medical records were available. The median serum prostate-specific antigen at diagnosis was 11 ng/ml with the clinical stage T1C in 9 patients, T2 in 68, and T3 in 29. The Gleason score on transrectal ultrasonography (TRUS) biopsy was < or =6 in 13, 7 in 41, and > or =8 in 52. A total of 93 patients had documented pretreatment digital rectal examination (DRE) findings: 54 had a unilaterally suspicious DRE, and 31 had a bilaterally suspicious DRE. Of patients with a unilaterally positive DRE, 30 had ipsilateral lymph node metastasis, 16 contralateral, and 8 bilateral. DRE showed a 71% sensitivity and 29% false-negative rate in predicting the side of nodal metastasis. A total of 98 patients had documented TRUS biopsy findings: 37 had unilaterally positive TRUS biopsies and 61 bilaterally positive biopsies. Of patients with unilaterally positive TRUS biopsies, 20 had ipsilateral lymph node metastasis, 11 contralateral, and 6 bilateral. TR...Continue Reading

References

Sep 17, 2005·Acta Oncologica·Per-Uno Malmström
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Hideaki MiyakeHiroshi Eto

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Citations

Nov 26, 2010·The American Journal of Surgical Pathology·Yuji TokudaSamson W Fine
Jul 11, 2013·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·R SchiavinaG Carmignani

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