PMID: 9425659Jan 13, 1998Paper

Can drugs be designed?

Current Opinion in Biotechnology
R E Hubbard

Abstract

Many examples are now emerging of the successful use of rational, structure-based methods in drug discovery. Of particular note is the development of imaginative NMR-based methods for rapid routes to ligand design. Our understanding of the chemistry underlying protein-ligand interactions, however, remains relatively poor and a major limitation in our ability to truly design drugs.

References

Aug 1, 1994·Journal of Computer-aided Molecular Design·R A Lewis, A R Leach
Dec 22, 1995·Journal of Medicinal Chemistry· Ajay, M A Murcko
Apr 1, 1996·Current Opinion in Structural Biology·P Bamborough, F E Cohen
Aug 1, 1996·Nature Structural Biology·N C StrynadkaJ B Jones
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Jun 1, 1997·Chemistry & Biology·N D Pearson, C D Prescott

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Citations

Feb 19, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Feng YangHong Liang
Nov 1, 2005·Drug Discovery Today·Geoffrey A Holdgate, Walter H J Ward
Mar 10, 2010·Evolutionary Computation·Milan MijajlovicDusan P Djurdjevic
Mar 11, 1999·Journal of Receptor and Signal Transduction Research·H Kubinyi
Oct 25, 2001·Journal of the American Chemical Society·H MaoS W Fesik

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