Can endoscopic injection of epinephrine prevent surgery in gastroduodenal ulcer bleeding? An analysis of 107 cases

Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a
Cemalettin ErtekinOrhan Alimoglu

Abstract

Gastroduodenal ulcers are still a common cause of severe upper gastrointestinal bleeding. Endoscopy has gained popularity worldwide over conventional open surgery for the treatment of upper gastrointestinal bleeding. This study aims to assess the efficacy of endoscopic injection of epinephrine in the treatment of gastroduodenal ulcer bleeding. This study was conducted between March 2000 and March 2003. We analyzed 107 consecutive patients admitted to our department of trauma and emergency surgery with upper gastrointestinal bleeding. Endoscopy was performed on all 107 patients and bleeding ulcers were treated with injection of diluted epinephrine. Recurrent bleeding was seen in 21 patients (19.6%), all of whom underwent a second endoscopy. Four patients (3.7%) required a third endoscopy session and nine patients (8.5%) needed surgery after endoscopy failed. There were two mortalities (1.9%). The nine patients who required surgery and the two patients who died were all in the Forrest Ia and Ib groups of acute UGI hemorrhage. Endoscopic injection therapy with epinephrine reduces operation rates and can be used safely in adequate hemostasis of gastroduodenal ulcers.

References

Nov 1, 1992·World Journal of Surgery·C P Steffes, C Sugawa
May 1, 1991·Gastrointestinal Endoscopy·T J WhittleM Raval
Jul 25, 1990·JAMA : the Journal of the American Medical Association·H S SacksD Pagano
Jul 1, 1990·Gastrointestinal Endoscopy·P B Cotton, J Baillie
Sep 8, 1989·JAMA : the Journal of the American Medical Association
Jan 1, 1986·Gastroenterology·D Fleischer
May 1, 1986·Endoscopy·F T de DombalA G Morgan
Jan 5, 1995·Deutsche medizinische Wochenschrift·C EllW Hohenberger
Sep 15, 1994·The New England Journal of Medicine·L Laine, W L Peterson
Apr 10, 1997·The New England Journal of Medicine·M S KhurooJ S Sodi
Apr 20, 1999·Digestion·R Meier, A R Wettstein
Feb 5, 2000·World Journal of Surgery·C OhmannH D Röher
Jan 9, 2001·Endoscopy·M E van LeerdamG N Tytgat
Jun 26, 2001·Alimentary Pharmacology & Therapeutics·J P GisbertJ M Pajares
Jun 27, 2002·Gastrointestinal Endoscopy·Jerome D WayeG N J Tytgat

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Citations

Jan 1, 2011·Case Reports in Gastrointestinal Medicine·Raffaele MantaGabrio Bassotti
Jul 9, 2010·World Journal of Gastroenterology : WJG·Grigoriy E Gurvits
Jun 28, 2013·World Journal of Gastrointestinal Surgery·Roosmarijn Lysbeth GroenveldAlaattin Ozdemir

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