Can EUS-guided FNA distinguish between gallbladder cancer and xanthogranulomatous cholecystitis?

Gastrointestinal Endoscopy
Susumu HijiokaKenji Yamao

Abstract

EUS-guided FNA (EUS-FNA) is a useful modality for sampling various targets, but its applicability to gallbladder (GB) mass lesions is limited. To determine the usefulness of EUS-FNA for diagnosing GB mass lesions. Single-center, retrospective, case-series study. Tertiary-care referral center. This study involved 15 consecutive patients who underwent EUS-FNA of GB mass lesions. We punctured GB masses in patients with suspected xanthogranulomatous cholecystitis to distinguish them from malignancy, and in patients with unresectable GB carcinoma for pathological confirmation. The final diagnosis was based on surgical histopathological results or follow-up outcome. EUS-FNA. Evaluation of EUS-FNA sampling adequacy rate and diagnostic yield. Xanthogranulomatous cholecystitis was suspected in 6 of the 15 patients. EUS-FNA revealed foam cells (n = 3), inflammatory cells (n = 1, proven by cholecystectomy), and GB carcinoma (n = 1), and the amount of the aspirate was insufficient in one case (xanthogranulomatous cholecystitis was later proven by extended hepatectomy). The mean follow-up period of the patients with xanthogranulomatous cholecystitis was 1177 days. Adenocarcinoma was confirmed by EUS-FNA in 8 of the 9 patients with suspected...Continue Reading

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