PMID: 6982649Jan 1, 1982Paper

Can experimental B cell tolerance serve as a model for self tolerance?

Annals of the New York Academy of Sciences
E DienerC A Waters

Abstract

We have examined the abilities of the mature and immature immune systems to discriminate between tolerogenic and nontolerogenic forms of a hapten-carrier conjugate; both forms are multivalent nonimmunogenic polymers of the same molecular weight, and have the same avidity for free, hapten-specific antibody and hapten-binding B cells. Hapten-specific tolerance was induced in adult B cells by nonimmunogenic dinitrophenylated carboxymethyl cellulose or methyl cellulose. Oxidation and subsequent reduction of the vicinal hydroxyl groups of both carriers aborgated tolerogenicity, although they remained nonimmunogenic. This chemical modification did not affect the carrier's molecular weight, and it did not reduce the binding avidity of their hapten derivatives to hapten-specific antibody or to antigen-binding B cells. The same experiments, when carried out in either neonatal mice or mice that had been lethally irradiated and given the above compounds during treatment with 13-day-old fetal liver cells, invariably yielded the same results. Like adult mice, these immunologically immature animals were capable of distinguishing between the tolerogenic and the nontolerogenic form of each antigen. It has also been shown (C. A. Waters et al., ...Continue Reading

References

Jun 1, 1976·The Journal of Experimental Medicine·E S Metcalf, N R Klinman
Jan 1, 1979·Immunological Reviews·E S MetcalfN R Klinman
Aug 1, 1975·Archives of Biochemistry and Biophysics·T P KingP S Norman
Sep 11, 1970·Science·P Bretscher, M Cohn
Feb 1, 1972·Cellular Immunology·R E ClickB J Alter
Sep 1, 1967·The Journal of Experimental Medicine·R I Mishell, R W Dutton
Jun 19, 1959·Science·J LEDERBERG
Oct 17, 1959·British Medical Journal·M BURNET

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