Can faecal calprotectin predict relapse in inflammatory bowel disease: a mini review

Frontline Gastroenterology
T S Chew, J C Mansfield

Abstract

Crohn's disease and ulcerative colitis are chronic inflammatory disorders affecting the gastrointestinal tract. Faecal calprotectin is a protein complex of the S-100 family of calcium-binding proteins present in inflammatory cells that can be measured in stool samples, which act as a biomarker for bowel inflammation. Elevated faecal calprotectin has been shown to reflect the presence of ongoing mucosal inflammation, which improves with mucosal healing. The aim of this review was to evaluate the available evidence on the ability of faecal calprotectin to predict a relapse in inflammatory bowel disease. Multiple retrospective studies have shown that patients who relapse have significantly higher levels of calprotectin in their stool compared with non-relapsers, especially in ulcerative colitis. Elevated faecal calprotectin postoperatively in Crohn's disease was also shown to be indicative of a relapse. However, the association of a raised faecal calprotectin and relapse is not universal and may be explained by the different patterns of mucosal inflammatory activity that exist. In conclusion, we put forward our hypothesis that changes such as a rise in faecal calprotectin levels may be more predictive of a relapse than absolute va...Continue Reading

References

Aug 2, 2001·Journal of Pediatric Gastroenterology and Nutrition·S K BunnB E Golden
Sep 20, 2008·The American Journal of Gastroenterology·Renata D'IncàGiacomo Carlo Sturniolo
Dec 23, 2008·Scandinavian Journal of Gastroenterology·Inger Camilla SolbergUNKNOWN IBSEN Study Group
Mar 18, 2009·Inflammatory Bowel Diseases·Javier P GisbertJosé Maté
Apr 23, 2009·The British Journal of Surgery·C A LambJ C Mansfield
Jul 8, 2009·European Journal of Gastroenterology & Hepatology·Lamia KallelAzza Filali
Apr 10, 2010·Scandinavian Journal of Gastroenterology·Taina Sipponen, Kaija-Leena Kolho
Dec 3, 2010·Journal of Crohn's & Colitis·Valle García-SánchezFederico Gómez-Camacho
Aug 24, 2012·Lancet·Daniel C Baumgart, William J Sandborn
Jan 1, 2011·Frontline Gastroenterology·C A Lamb, J C Mansfield
Feb 26, 2014·Journal of Crohn's & Colitis·Graham D NaismithDaniel R Gaya
Nov 6, 2014·Scandinavian Journal of Gastroenterology·Gian Paolo CavigliaFrancesca Bresso
Mar 27, 2015·Journal of Clinical Gastroenterology·Rocio Ferreiro-IglesiasJuan Enrique Dominguez-Muñoz
Jun 9, 2015·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Klaus TheedeAnette Mertz Nielsen
Aug 27, 2015·European Journal of Gastroenterology & Hepatology·Eleonora ScaioliAndrea Belluzzi
Nov 26, 2015·Scandinavian Journal of Gastroenterology·Rocio Ferreiro-IglesiasJuan Enrique Dominguez-Muñoz

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Citations

Mar 20, 2019·World Journal of Gastroenterology : WJG·Alice Jane FosterKevan Jacobson
Jul 12, 2018·Disease Markers·Alicja DerkaczKatarzyna Komosinska-Vassev
Apr 14, 2020·JGH Open : an Open Access Journal of Gastroenterology and Hepatology·Dharshan SathananthanRobert V Bryant
Jul 24, 2021·Alimentary Pharmacology & Therapeutics·Nicolas PierreEdouard Louis

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