Can finger-prick sampling replace venous sampling to determine the pharmacokinetic profile of oral paracetamol?

British Journal of Clinical Pharmacology
Baba S MohammedJames S McLay

Abstract

WHAT IS ALREADY KNOWN ABOUT THE SUBJECT: Finger-prick blood samples are increasingly used for the clinical and biomedical measurement of drugs and endogenous substance concentration. The use of different sampling sites can give rise to different drug concentration measurements. During the absorption phase, the paracetamol concentration in finger-prick blood samples is significantly greater than that in venous blood samples, following oral administration. Finger-prick and venous blood samples will result in equivalent pharmacokinetic parameters of oral paracetamol only after distribution equilibrium is attained. The drive to increase the availability of paediatric pharmacokinetic data with minimum blood loss has led to the development of micro-sampling techniques. However studies have suggested that pharmacokinetic data from venous or capillary blood samples may not be directly comparable. The aim of this study was to determine whether paracetamol demonstrates concentration differences between finger-prick and venous blood samples. Paired finger-prick and venous blood samples were taken at 0, 15, 30 and 60 min following 1 g oral paracetamol, from 12 male adult subjects. Paracetamol concentration was determined using HPLC and UV ...Continue Reading

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Citations

Jul 2, 2014·Clinical Pharmacokinetics·Pieter M M De KeselChristophe P Stove
Aug 14, 2013·Bioanalysis·Pieter Mm De KeselChristophe P Stove
Aug 5, 2015·Clinical Pharmacokinetics·Pieter M M De KeselChristophe P Stove
Apr 5, 2012·The Journal of Pharmacy and Pharmacology·Anneliese M Rittau, Andrew J McLachlan
Apr 3, 2014·Drug Testing and Analysis·Abhisheak SharmaJawahar Lal
Sep 18, 2015·Bioanalysis·Julien DéglonAurélien Thomas
Jul 9, 2016·Journal of Pharmaceutical and Biomedical Analysis·Yeliz EnderleJürgen Burhenne
Oct 5, 2016·Journal of Pharmaceutical and Biomedical Analysis·Nele SadonesChristophe P Stove
Dec 5, 2018·Biomedical Chromatography : BMC·Suresh P SulochanaRamesh Mullangi
Feb 22, 2012·Critical Reviews in Toxicology·Christophe P StoveWilly E Lambert
Apr 29, 2020·Diagnostics·Kristina MalsagovaAnna Kaysheva

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