Can follicle-stimulating hormone be used to define menopausal status?

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
R K StellatoC Longcope

Abstract

To assess the ability of the level of follicle-stimulating hormone (FSH) to distinguish among premenopausal, perimenopausal, and postmenopausal women. We examined cross-sectional and longitudinal data from the second phase of the Massachusetts Women's Health Study (1986 to 1995), a population-based cohort of 427 premenopausal and perimenopausal women identified from the first phase of the Massachusetts Women's Health Study (1981 to 1986). Boxplots of FSH levels throughout the menopausal transition displayed considerable overlap. Logistic regressions and their resulting receiver operating characteristic curves further demonstrated that, although FSH is a statistically significant predictor of menopausal status, no single value of FSH is expedient for distinguishing premenopausal from perimenopausal or perimenopausal from postmenopausal women. FSH alone is not an effective predictor of transition into the perimenopausal or postmenopausal period. Specifically, the frequently recommended FSH cutoff of 40 IU/L is inappropriate by itself for clinical determination of postmenopausal status.

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Citations

May 29, 2010·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Michelle B RisslingSonia Ancoli-Israel
Oct 25, 2002·Journal of Vascular and Interventional Radiology : JVIR·Adel AhmadKenneth Najarian
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Oct 22, 2003·Clinics in Geriatric Medicine·Margaret-Mary G Wilson

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