PMID: 6107590Nov 1, 1980Paper

Can food influence the absorption of methotrexate in children with acute lymphoblastic leukaemia?

Lancet
C R PinkertonJ M Bridges

Abstract

Serum levels of methotrexate (MTX) were measured in 10 children with acute lymphoblastic leukaemia over a 4 hour period after oral administration. The drug was given to each child on three occasions: first, with no food, then with a milky meal, and finally with a citrus meal. Peak serum MTX levels were significantly reduced by the milky meal and both meals delayed drug absorption in most children. The area under the absorption curve was also significantly reduced by the milky meal. Thus, for maximum serum levels, MTX should not be given with food, and if patients are to be grouped on the basis of their MTX absorption profile this should be determined under standard conditions in relation to meals.

References

Jan 1, 1979·Cancer Chemotherapy and Pharmacology·P J KearneyM G Mott
Aug 10, 1968·Lancet·G W HepnerD L Mollin
Nov 30, 1971·Annals of the New York Academy of Sciences·I D Goldman
Jan 16, 1971·British Medical Journal·A BennM E Smith
Jun 1, 1957·The Journal of Pharmacy and Pharmacology·B B BRODIE, C A HOGBEN

❮ Previous
Next ❯

Citations

Jan 1, 1987·Cancer Chemotherapy and Pharmacology·A D PearsonJ M Chessells
Jan 1, 1986·European Journal of Clinical Pharmacology·H Schrøder, E K Foged
Oct 6, 1997·Clinics in Dermatology·S SaidG D Weinstein
Dec 1, 1990·Baillière's Clinical Rheumatology·N Songsiridej, D E Furst
Jun 1, 1997·Alimentary Pharmacology & Therapeutics·M MoshkowitzT Gilat
Nov 16, 1996·BMJ : British Medical Journal·J S Lilleyman, L Lennard
Jan 25, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Wei ChouJaung-Geng Lin
Mar 25, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Wendy LandierSmita Bhatia
Jun 1, 1987·Journal of Clinical Pharmacy and Therapeutics·S M DonohueI M Franklin
Jul 1, 1992·Arthritis and Rheumatism·G D KozloskiJ B Johnson
Sep 1, 1996·Pediatric Hematology and Oncology·J S Lilleyman
Mar 1, 1987·JPEN. Journal of Parenteral and Enteral Nutrition·L P HarveyJ M Daly
Feb 1, 1982·Royal Society of Health Journal·H J Rogers
Jan 7, 1999·International Journal of Cancer. Supplement = Journal International Du Cancer. Supplement·D J MurryD G Poplack
Dec 14, 2006·Journal of Pediatric Hematology/oncology·Michelle T PritchardJohn A Duley
Jun 24, 2006·Nature Reviews. Cancer·Charity D Scripture, William D Figg
Nov 13, 2001·American Journal of Clinical Dermatology·A L Kuijpers, P C van de Kerkhof
Jul 3, 2002·Drugs·Lars E Schmidt, Kim Dalhoff
Dec 27, 2019·Human & Experimental Toxicology·T HiguchiH Furukawa
Jan 1, 1986·Medical and Pediatric Oncology·R RiccardiR Mastrangelo
Nov 23, 2013·Pediatric Blood & Cancer·Kim K B ClemmensenUNKNOWN Nordic Society of Pediatric Hematology, Oncology (NOPHO)
Jul 1, 1986·Pharmacotherapy·D R MillerJ J Fiechtner
Dec 1, 1993·The Annals of Pharmacotherapy·M E TeresiJ P O'Donnell
Jul 13, 2018·Pediatric Rheumatology Online Journal·Giovanna FerraraUNKNOWN Rheumatology Italian Study Group
Jan 1, 1989·Pediatric Hematology and Oncology·G LönnerholmU Myrdal
Jan 2, 1989·The Medical Journal of Australia·P J Neuvonen, K T Kivistö
Jan 1, 1990·Critical Reviews in Oncology/hematology·D R Miller, L P Miller
Mar 1, 1983·Cancer Treatment Reviews·J H Schornagel, J G McVie
Jan 1, 1989·Medical Oncology and Tumor Pharmacotherapy·P LafolieC Peterson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.