Can fructose influence the development of obesity mediated through hypothalamic alterations?

Journal of Neuroscience Research
Anderson Cargnin-CarvalhoGislaine Tezza Rezin

Abstract

Epidemiological data from the last decades point to an exponential growth in the number of obese people. Different behavioral factors, mainly associated with food consumption, appear to contribute significantly to its development. Concomitant with increased obesity rates, an increase in the consumption of fructose has been observed; therefore, fructose consumption has been implicated as an important obesogenic factor. However, changes in brain activity due to fructose consumption are possible, especially in relation to hypothalamic satiety mechanisms. In addition, the obese state may provide an environment of chronic inflammation and further contribute to the discontinuation of satiety mechanisms in the hypothalamus. We briefly review the intrinsic alterations to the increased adipose tissue, its connections with the hypothalamus in the control of energy signaling mechanisms and, consequently, the participation of fructose as a co-adjuvant or trigger. Presenting the current context with clinical trials involving human and animal studies, we seek to contribute to a better understanding of the role of fructose in the progression of obesity.

References

Jul 1, 1976·Clinics in Endocrinology and Metabolism·J Hirsch, B Batchelor
Oct 31, 1998·Nature·J M Friedman, J L Halaas
Nov 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Michael J WolfgangM Daniel Lane
Aug 16, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alexandra ShapiroPhilip J Scarpace
Sep 9, 2008·Endocrinology and Metabolism Clinics of North America·Nils HalbergPhilipp E Scherer
Oct 31, 2008·Proceedings of the National Academy of Sciences of the United States of America·Seung Hun ChaM Daniel Lane
Jun 9, 2009·Neurobiology of Learning and Memory·A P RossM B Parent
Aug 25, 2009·The Proceedings of the Nutrition Society·I Stuart WoodPaul Trayhurn
Jan 21, 2010·Physiological Reviews·Luc Tappy, Kim-Anne Lê
Mar 5, 2010·Clinical Pharmacology and Therapeutics·P MathieuJ-P Després
Sep 9, 2010·American Journal of Physiology. Endocrinology and Metabolism·Mark J DekkerKhosrow Adeli
Jun 3, 2011·The Journal of Clinical Investigation·Kai SunPhilipp E Scherer
Aug 30, 2011·Lancet·Boyd A SwinburnSteven L Gortmaker
Dec 29, 2011·The Journal of Clinical Investigation·Joshua P ThalerMichael W Schwartz
Jan 10, 2012·Nutrition Reviews·Barry M PopkinShu Wen Ng
Aug 15, 2012·Immunological Reviews·Amy R JohnsonLiza Makowski
Jan 3, 2013·JAMA : the Journal of the American Medical Association·Kathleen A PageRobert S Sherwin
Feb 19, 2013·Public Health Nutrition·Mario SiervoJonathan C K Wells
Aug 6, 2013·Neuroscience and Biobehavioral Reviews·Gabi SheferNaftali Stern
Jan 10, 2014·The Journal of Endocrinology·Haiming Cao
Apr 15, 2014·Brain, Behavior, and Immunity·Alyson A Miller, Sarah J Spencer
May 21, 2014·Nature Reviews. Neuroscience·Gregory J MortonMichael W Schwartz
Jun 12, 2014·United European Gastroenterology Journal·Clive H Wilder-SmithRonaldo P Ferraris
Oct 11, 2014·Molecular Nutrition & Food Research·Jian-Mei LiLing-Dong Kong
Dec 3, 2014·Physiology & Behavior·Danielle L Colley, Thomas W Castonguay
Feb 11, 2015·Annual Review of Physiology·Martin ValdearcosSuneil K Koliwad
Apr 1, 2015·Nature Reviews. Endocrinology·Stefanie KälinChun-Xia Yi
May 13, 2015·Hormone Molecular Biology and Clinical Investigation·Bérénice CharrezLionel Hebbard
Apr 18, 2016·Metabolism: Clinical and Experimental·Olivia M FarrChristos S Mantzoros
Apr 22, 2016·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K LowetteP Vanden Berghe
May 22, 2016·Diabetes·Ania M JastreboffSonia Caprio
Oct 22, 2016·Annals of the New York Academy of Sciences·Alexandre Caron, Denis Richard
Dec 31, 2016·Brain Research·Sarah A OppeltDean R Tolan
Feb 27, 2017·Trends in Cell Biology·Leen Catrysse, Geert van Loo
Mar 10, 2017·Nutrients·Prasanthi Jegatheesan, Jean-Pascal De Bandt
Mar 10, 2017·Nutritional Neuroscience·Viviane Wagner RamosKelse Tibau Albuquerque
May 10, 2017·Biological Psychology·Rajita Sinha

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Citations

Nov 28, 2020·Genes & Nutrition·Giulia TiniMarie-Pier Scott-Boyer

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