Can growth hormone counteract the catabolic effects of steroids?

Hormone Research
Nelly Mauras

Abstract

Chronic administration of glucocorticosteroids (GCs) can have significant catabolic effects in vivo in a host of metabolic systems, including amino acid metabolism, skeletal muscle, bone and linear growth. GCs inhibit protein synthesis and increase protein breakdown at the skeletal muscle and whole-body level and impair growth hormone (GH) secretion and action. Conversely, GH and insulin-like growth factor I (IGF-I) are potent protein-anabolic and growth-promoting agents in vitro and in vivo. This review summarizes both the catabolic effects of GCs and the anabolic and metabolic effects of GH and IGF-I. Both GH and IGF-I may decrease the catabolic effects of chronic steroid use in humans, particularly by enhancing lean body mass accrual and, in children, by increasing linear growth.

Citations

Mar 1, 2012·Trends in Endocrinology and Metabolism : TEM·Peter Rotwein
Apr 22, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Marie-Louise Hyre ArpeThomas Leth Frandsen
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Sep 30, 2010·Nature Reviews. Endocrinology·Hermann L Müller
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Sep 4, 2015·Physiological Genomics·Damir AlzhanovPeter Rotwein
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