Can helical CT replace scintigraphy in the diagnostic process in suspected pulmonary embolism? A retrolective-prolective cohort study focusing on total diagnostic yield

European Radiology
A B van RossumH G Heijerman

Abstract

The aim of our study was to compare the diagnostic value of helical CT vs that of ventilation-perfusion (V/Q) scintigraphy as a first-line test in a diagnostic strategy in patients suspected of pulmonary embolism (PE). In a retrolective-prolective cohort study we tested the accuracy of helical CT vs V/Q scintigraphy in 123 patients suspected of PE. A diagnostic panel was asked to formulate the presumptive diagnosis on the presence or absence of PE, or of alternative disease by using two competing diagnostic strategies. These consisted of the patient history, laboratory tests and chest X-ray (together baseline tests) in combination with either helical CT or V/Q scintigraphy (CT strategy and V/Q strategy, respectively). The results were compared with the final diagnosis in each patient that was established from various reference tests (which included V/Q scintigraphy, pulmonary angiography and clinical follow-up). The CT and V/Q strategies were compared with regard to the accuracy for PE, for alternative diseases and with regard to the proportion of conclusive diagnoses that were made. The CT strategy was more accurate than the V/Q strategy for detecting or excluding PE. Sensitivity and specificity were 49 and 74 % for the V/Q st...Continue Reading

Citations

Jul 13, 2007·Der Radiologe·J GellissenT Helmberger
Sep 21, 2004·European Journal of Nuclear Medicine and Molecular Imaging·Carl Schuemichen
Mar 8, 2007·European Radiology·Andrew Frederick ScarsbrookFergus Vincent Gleeson
May 27, 2005·The International Journal of Cardiovascular Imaging·U Joseph Schoepf
Jul 12, 2003·Seminars in Roentgenology·U Joseph Schoepf, Philip Costello
Jun 5, 2003·Current Problems in Diagnostic Radiology·Lacey Washington, Meltem Gulsun
Oct 3, 2002·The Journal of Emergency Medicine·Dan S MoselyCurtis J Hunter
Oct 28, 2003·Clinical Nuclear Medicine·Jean LetteAndré Levasseur
May 31, 2006·Australasian Radiology·R M SubramaniamN Karalus
Nov 9, 2007·Postgraduate Medical Journal·Joshua BurrillMohamed Hamady
May 31, 2003·Thorax·UNKNOWN British Thoracic Society Standards of Care Committee Pulmonary Embolism Guideline Development Group
Oct 7, 2004·Respiration; International Review of Thoracic Diseases·Claus Kroegel, Angelika Reissig
Jun 14, 2000·AJR. American Journal of Roentgenology·T P Smith
Aug 1, 2000·AJR. American Journal of Roentgenology·M Remy-JardinA Duhamel
Sep 9, 1999·Radiology·M Remy-Jardin, J Remy
Jul 21, 2000·Radiographics : a Review Publication of the Radiological Society of North America, Inc·L R Goodman
Aug 8, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Franck LacoeuilleJean Jacques Le Jeune
Jan 25, 2002·The British Journal of Radiology·S P G Padley
Nov 18, 2004·The British Journal of Radiology·J H Reid
Jan 31, 2004·Radiology·U Joseph Schoepf, Philip Costello
Jan 13, 2001·Mayo Clinic Proceedings·J H RyuP A Pellikka
Sep 9, 2008·European Journal of Radiology·Sven F ThiemeThorsten R C Johnson
Jan 15, 2002·Journal of Vascular and Interventional Radiology : JVIR·Matthew S Johnson
Oct 26, 2005·Journal of Thrombosis and Haemostasis : JTH·M J L van StrijenUNKNOWN Antelope-Study Group
Apr 9, 2005·The American Heart Hospital Journal·Rene Quiroz, U Joseph Schoepf
Nov 20, 2003·Seminars in Nuclear Medicine·Daniel F Worsley, Abass Alavi
Jul 10, 2002·Seminars in Nuclear Medicine·Hiroto HatabuWarren B Gefter
Jan 12, 2005·Clinical Radiology·S J McKieJ T Murchison
Mar 1, 2005·Seminars in Roentgenology·James G RavenelU Joseph Schoepf
Jan 13, 2004·The American Journal of Medicine·Robert L TrowbridgeAndrew D Auerbach
Sep 5, 2003·Seminars in Ultrasound, CT, and MR·Sharyn L S MacDonald, John R Mayo
Dec 17, 2005·Clinical Radiology·A F ScarsbrookF V Gleeson
Apr 26, 2005·Radiologic Clinics of North America·Caroline Chiles, J Jeffrey Carr

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