Can homeostatic plasticity in deafferented primary auditory cortex lead to travelling waves of excitation?

Journal of Computational Neuroscience
Michael ChrostowskiSuzanna Becker

Abstract

Travelling waves of activity in neural circuits have been proposed as a mechanism underlying a variety of neurological disorders, including epileptic seizures, migraine auras and brain injury. The highly influential Wilson-Cowan cortical model describes the dynamics of a network of excitatory and inhibitory neurons. The Wilson-Cowan equations predict travelling waves of activity in rate-based models that have sufficiently reduced levels of lateral inhibition. Travelling waves of excitation may play a role in functional changes in the auditory cortex after hearing loss. We propose that down-regulation of lateral inhibition may be induced in deafferented cortex via homeostatic plasticity mechanisms. We use the Wilson-Cowan equations to construct a spiking model of the primary auditory cortex that includes a novel, mathematically formalized description of homeostatic plasticity. In our model, the homeostatic mechanisms respond to hearing loss by reducing inhibition and increasing excitation, producing conditions under which travelling waves of excitation can emerge. However, our model predicts that the presence of spontaneous activity prevents the development of long-range travelling waves of excitation. Rather, our simulations sh...Continue Reading

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Citations

Jan 1, 2014·Hearing Research·Roland Schaette
Sep 8, 2015·Journal of Computational Neuroscience·Markéta TomkováCyril Brom
Jul 16, 2014·Neural Plasticity·Massimo SalviatiGiancarlo Cianfrone
Sep 10, 2013·Hearing Research·Farhait KianiRoland Schaette
Mar 6, 2015·Frontiers in Neurology·Jos J Eggermont, Peter A Tass
Jun 7, 2014·Frontiers in Neuroscience·Joshua R Gold, Victoria M Bajo
Dec 6, 2014·American Journal of Audiology·Martin PienkowskiBrian C J Moore
Dec 5, 2019·The Journal of the Acoustical Society of America·Naomi F BramhallDawn Konrad-Martin
Feb 11, 2020·Frontiers in Computational Neuroscience·Isma ZulfiqarElia Formisano
Jul 24, 2013·Neuroscience and Biobehavioral Reviews·Larry E RobertsJos J Eggermont

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