Can iliac crest reconstruction reduce donor site morbidity?: a study using degradable hydroxyapatite-bioactive glass ceramic composite

Journal of Spinal Disorders & Techniques
Narayana K AcharyaVenugopal K Menon

Abstract

Prospective study. To prospectively validate the hypothesis that iliac crest donor site morbidity may be a structural issue and by reconstructing the crest its incidence might be reduced. The study also evaluates the efficacy of Chitra hydroxyapatite-bioactive glass ceramic composite (Chitra-HABG) as a material for reconstructing the iliac crest. Tricortical iliac crest bone graft harvesting is associated with significant donor site morbidity, varying from 3% to 61%. Reconstruction of the defect has been shown to reduce this morbidity, but the only materials which have been shown to be useful and readily available are bioactive apatite-wollastonite glass ceramic and morcellized beta-tricalcium phosphate. Twenty-six patients in whom tricortical graft was harvested from the iliac crest and defect reconstructed with an indigenously developed and tested graft substitute-Chitra HABG-were followed up to duration of 1 year. Outcome measures were donor site morbidity as assessed clinically and radiologic assessment for ceramic incorporation, dissolution, fragmentation, and migration. At the end of 1 year from surgery, 25 of the 26 patients (96.15%) had no pain at the donor site, which had been reconstructed. Radiologic evaluation showe...Continue Reading

References

Jan 1, 1989·Journal of Orthopaedic Trauma·E M Younger, M W Chapman
Mar 1, 1988·Spine·S H HochschulerR G Johnson
Jan 1, 1994·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·S AsanoM Fujiya
May 1, 1997·The Journal of Bone and Joint Surgery. American Volume·N R Colterjohn, D A Bednar
Feb 9, 2000·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·H L Defino, A E Rodriguez-Fuentes
Feb 14, 2002·Neurosurgery·Robert F HearyCristian Brotea
Jul 9, 2004·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Manabu ItoKiyoshi Kaneda

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Citations

Jun 26, 2012·International Orthopaedics·Konstantinos G MakridisPeter V Giannoudis
Sep 21, 2013·Biomaterials·Arumugan SabareeswaranArtemis Stamboulis
Nov 10, 2013·Journal of Pediatric Orthopedics. Part B·Balasubramanian BalakumarVrisha Madhuri

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