Can inflammatory pain prevent the development of acute tolerance to alfentanil?

Anesthesia and Analgesia
I KissinE L Bradley

Abstract

Constant pain could, in principle, counteract mobilization of antianalgesia systems and prevent the development of acute tolerance to the analgesic effects of opioids. We sought to determine whether a tonic nociceptive input caused by inflammation inhibits the development of acute tolerance to alfentanil. The inflammation was induced by injection of carrageenan into the rat hind paw. A threshold of motor response to increasing pressure on the paw was used to determine analgesia. Alfentanil was administered IV with an infusion algorithm designed to maintain a constant plasma level of opioid for 4 h. The degree of acute tolerance was determined on the basis of decline in the level of analgesia. The continuous decline of the analgesic effect from its peak at 30 min to the end of the 4-h infusion period was profound, despite the constant-rate infusion of alfentanil. The degrees of decline were very similar in rats with and without carrageenan-induced inflammation (from 242 +/- 31 to 154 +/- 20 g, P < 0.0001; and from 242 +/- 33 to 148 +/- 14 g, P < 0.0001, respectively). The results suggest that inflammatory nociceptive input does not prevent the development of acute tolerance to opioid-induced analgesia measured as an increased re...Continue Reading

References

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Citations

Nov 23, 2005·Anesthesia and Analgesia·Igor Kissin
Apr 19, 2007·Clinical and Experimental Pharmacology & Physiology·Stephen R EdwardsMaree T Smith
Nov 15, 2001·Current Psychiatry Reports·J Streltzer

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