PMID: 11920464Mar 29, 2002Paper

Can initial prostate specific antigen determinations eliminate the need for bone scans in patients with newly diagnosed prostate carcinoma? A multicenter retrospective study in Japan

Cancer
Shigeru KosudaHirofumi Fujii

Abstract

The objective of the current study was to assess rigorously whether serum prostate specific antigen (PSA) determination can eliminate the need for bone scans in Japanese patients with newly diagnosed prostate carcinoma with serum PSA levels < or = 10 ng/mL. A retrospective assessment of 1294 patients with newly diagnosed, untreated prostate carcinoma was conducted at the authors' institutions. All patients underwent a bone scan, serum PSA measurement, and core needle biopsy of the prostate. The receiver operating characteristic curve for identifying a positive bone scan based on serum PSA levels and a decision tree were analyzed to determine the expected 10-year cumulative cost and disease specific survival rate. Two competing strategies were used: PSA alone and PSA plus baseline bone scan. For the PSA-alone strategy, a baseline bone scan was performed only when the patient had a serum PSA level > 10 ng/mL. The proportion of positive bone scans in patients with serum PSA levels < or = 10.0 ng/mL was 1.33%. The area under the receiver operating characteristic curve was 0.870. Patients with a Gleason Grade > or = 3 tumors or with a Gleason score > or = 7 had a higher proportion of positive bone scans. The 10-year disease specific...Continue Reading

Citations

Jul 23, 2011·World Journal of Urology·Seung Hwan LeeByung Ha Chung
Mar 13, 2013·Revista española de medicina nuclear e imagen molecular·M MoslehiA Gholamrezanezhad
Dec 17, 2008·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·D VilainC Tainturier
Dec 13, 2006·Radiologic Clinics of North America·Oguz Akin, Hedvig Hricak
Sep 22, 2005·International Journal of Urology : Official Journal of the Japanese Urological Association·Osamu IshizukaOsamu Nishizawa
May 6, 2004·The Journal of Urology·Sadeq AbuzalloufHimu Lukka
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Christopher Chee Kong HoAzad H A Razack
Jun 5, 2010·Journal of the American College of Radiology : JACR·Catherine C RobertsStephen T Lutz

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