Can intensive care unit delirium be prevented and reduced? Lessons learned and future directions

Annals of the American Thoracic Society
S Jean HsiehMichelle N Gong

Abstract

Delirium is a form of acute brain injury that occurs in up to 80% of critically ill patients. It is a source of enormous societal and financial burdens due to increased mortality, prolonged intensive care unit (ICU) and hospital stays, and long-term neuropsychological and functional deficits in ICU survivors. These poor outcomes are not only independently associated with the development of delirium but are also associated with increasing delirium duration. Therefore, interventions should strive both to prevent the occurrence of ICU delirium and to limit its persistence. Both patient-centered and ICU-acquired risk factors need to be addressed early in the ICU course to maximize the efficacy of prevention strategies and to improve long-term outcomes of ICU patients. In this article, we review strategies for early detection of patients who are delirious and who are at high risk for developing delirium, and we present a clinically useful ICU delirium prevention and reduction strategy for clinicians to incorporate into their daily practice.

Associated Clinical Trials

References

Jun 13, 1998·Journal of General Internal Medicine·S K InouyeP Pompei
Mar 4, 1999·The New England Journal of Medicine·S K InouyeL M Cooney
May 18, 2000·The New England Journal of Medicine·J P KressJ B Hall
Jun 30, 2001·Intensive Care Medicine·N BergeronY Skrobik
Aug 21, 2001·Intensive Care Medicine·M J DuboisY Skrobik
Jan 18, 2002·Intensive Care Medicine·E W ElyS K Inouye
Feb 6, 2002·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·UNKNOWN American College of Critical Care Medicine of the Society of Critical Care Medicine, American Society of Health-System Pharm
Mar 14, 2002·Journal of the American Geriatrics Society·J McCuskerL Ramman-Haddad
Mar 21, 2002·Critical Care Medicine·Judith JacobiUNKNOWN Task Force of the American College of Critical Care Medicine (ACCM) of the Society of Critical Care Medicine (SCCM), America
Dec 11, 2002·JAMA : the Journal of the American Medical Association·Bernard De JongheUNKNOWN Groupe de Réflexion et d'Etude des Neuromyopathies en Réanimation
Feb 25, 2003·American Journal of Respiratory and Critical Care Medicine·Jonathan Y GaborPatrick J Hanly
Jun 12, 2003·JAMA : the Journal of the American Medical Association·E Wesley ElyGordon R Bernard
Apr 9, 2004·Critical Care Medicine·Eric B MilbrandtE Wesley Ely
Apr 15, 2004·JAMA : the Journal of the American Medical Association·E Wesley ElyRobert S Dittus
Jan 13, 2005·Critical Care Medicine·Bernard De JongheHervé Outin
Mar 23, 2006·Journal of the American Geriatrics Society·Josh F PetersonE Wesley Ely
Apr 21, 2006·Critical Care Medicine·Gerald ChanquesJean-Jacques Eledjam
Aug 22, 2006·Critical Care : the Official Journal of the Critical Care Forum·Margaret A PisaniSharon K Inouye
Nov 15, 2006·Intensive Care Medicine·Sébastien OuimetYoanna Skrobik
Nov 30, 2006·Critical Care Medicine·E Wesley ElyDaniel T Laskowitz
May 15, 2007·Chest·William D Schweickert, Jesse Hall
Aug 19, 2007·Archives of Internal Medicine·Margaret A PisaniSharon K Inouye
Oct 16, 2007·Anaesthesia and Intensive Care·U Prakanrattana, S Prapaitrakool
Dec 13, 2007·JAMA : the Journal of the American Medical Association·Pratik P PandharipandeE Wesley Ely
Jun 17, 2008·Critical Care Medicine·Sangeeta MehtaUNKNOWN Canadian Critical Care Trials Group
Jul 4, 2008·Critical Care Medicine·Peter E MorrisEdward Haponik
Dec 4, 2008·Critical Care Medicine·Margaret A PisaniSharon K Inouye
Jan 22, 2009·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Jin H HanE Wesley Ely
Feb 4, 2009·JAMA : the Journal of the American Medical Association·Richard R RikerUNKNOWN SEDCOM (Safety and Efficacy of Dexmedetomidine Compared With Midazolam) Study Group
Apr 8, 2009·Chest·Brian L ErstadCurtis N Sessler
Apr 8, 2009·Intensive Care Medicine·Peter E SpronkJohannes H Rommes
May 22, 2009·Critical Care : the Official Journal of the Critical Care Forum·Bart Van RompaeyLeo Bossaert
Jul 2, 2009·Psychosomatics·José R MaldonadoBruce A Reitz
Sep 12, 2009·American Journal of Respiratory and Critical Care Medicine·Margaret A PisaniPeter H Van Ness

❮ Previous
Next ❯

Citations

Jun 18, 2014·Annals of the American Thoracic Society·Constantine Manthous
Jun 18, 2014·Annals of the American Thoracic Society·S Jean HsiehMichelle N Gong
Dec 7, 2018·Critical Care Medicine·Cameron GreenRavindranath Tiruvoipati
Oct 13, 2019·Journal of Nursing Management·Carmen E Capo-LugoErik H Hoyer
Sep 29, 2019·JMIR Medical Informatics·Hani Nabeel MuftiSyed Sibte Raza Abidi
May 4, 2017·Annals of the American Thoracic Society·Ramona O HopkinsDale M Needham
Dec 8, 2017·Dementia & Neuropsychologia·Fei CaoAntonio L Teixeira
Apr 20, 2018·Journal of the American Geriatrics Society·Brianna RosgenKirsten M Fiest
Jul 26, 2017·Internal and Emergency Medicine·Giuseppe BellelliFrancesco Perticone
Dec 18, 2020·Critical Care Medicine·Shan ZhangYing Wu
Dec 1, 2020·American Heart Journal·Alejandro Cortés-BeringolaHéctor Bueno
Oct 19, 2020·Journal of Cardiothoracic and Vascular Anesthesia·Jason OchrochJesse Raiten
Apr 9, 2021·PloS One·Justin K BanerdtDouglas C Heimburger
Nov 3, 2020·The Nursing Clinics of North America·Stacey G BrowningClare Thomson-Smith
Jun 5, 2021·Journal of Neurology·Daniel AntonielloCharles Esenwa
Jun 29, 2021·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Rubina K MahajanParshotam L Gautam
Aug 18, 2021·Journal of the American Medical Informatics Association : JAMIA·Chao YanYou Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.