Can intradermal administration of angiotensin II influence human heat loss responses during whole body heat stress?

Journal of Applied Physiology
Naoto FujiiGlen P Kenny

Abstract

It is unclear if angiotensin II, which can increase the production of reactive oxygen species (oxidative stress), modulates heat loss responses of cutaneous blood flow and sweating. We tested the hypothesis that angiotensin II-induced increases in oxidative stress impair cutaneous perfusion and sweating during rest and exercise in the heat. Eleven young (24 ± 4 yr) healthy adults performed two 30-min cycling bouts at a fixed rate of metabolic heat production (400 W) in the heat (35°C). The first and second exercises were followed by a 20- and 40-min recovery. Four microdialysis fibers were placed in the forearm skin for continuous administration of either: 1) lactated Ringer (control), 2) 10 μM angiotensin II, 3) 10 mM ascorbate (an antioxidant), or 4) a combination of 10 μM angiotensin II + 10 mM ascorbate. Cutaneous vascular conductance (CVC; laser-Doppler perfusion units/mean arterial pressure) and sweating (ventilated capsule) were evaluated at each skin site. Compared with control, angiotensin II reduced both CVC and sweating at baseline resting and during each recovery in the heat (all P < 0.05). However, during both exercise bouts, there were no differences in CVC or sweating between the treatment sites (all P > 0.05). W...Continue Reading

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Citations

Dec 1, 2018·American Journal of Physiology. Heart and Circulatory Physiology·James A Lang, Alex C Krajek
Mar 31, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Ryan McGinnGlen P Kenny
Sep 22, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brendan D McNeelyGlen P Kenny

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