Can Intraoperative Low-Dose R ,S -Ketamine Prevent Depressive Symptoms After Surgery? The First Meta-Analysis of Clinical Trials

Frontiers in Pharmacology
Liwei PangShuodong Wu

Abstract

Background: Postoperative depression is a common complication after surgery that profoundly affects recovery and prognosis. New research indicates that (R,S)-ketamine is a potent antidepressant that exerts a rapid and sustained antidepressive effect. However, there is no consensus on whether intraoperative low-dose (R,S)-ketamine prevents postoperative depression. Objectives: This study aimed to investigate the safety, feasibility, and short-term complications of intraoperative low-dose (R,S)-ketamine in preventing postoperative depressive symptoms. Methods: The Web of Science, Cochrane, PubMed, and CNKI databases were systematically searched (last search February 28, 2020) to identify studies involving ketamine. Sensitivity and metaregression analyses were performed to identify potential confounders. The meta-analysis was performed using Review Manager 5.3. Results: A total of 13 studies (seven in Chinese and six in English) representing 1,148 cases of patients who were treated with (R,S)-ketamine and 874 cases of patients who received other treatments were included in the meta-analysis. Anesthesia duration and blood loss did not significantly differ between the two groups, demonstrating that (R,S)-ketamine was safe (odds rati...Continue Reading

References

Feb 25, 2000·Biological Psychiatry·R M BermanJ H Krystal
Jun 29, 2002·Anesthesia and Analgesia·Akira KudohTomoko Takazawa
Apr 2, 2011·Journal of the American Geriatrics Society·J Craig Nelson, Davangere P Devanand
Dec 30, 2011·Clinical Pharmacology and Therapeutics·J W Murrough
Jan 17, 2012·The Journal of Clinical Psychiatry·Enrico TedeschiniGeorge I Papakostas
Dec 10, 2013·Pharmacology, Biochemistry, and Behavior·Ji-Chun ZhangKenji Hashimoto
Oct 9, 2014·The Journal of Clinical Psychiatry·Dawn F IonescuCarlos A Zarate
Nov 8, 2014·Journal of Neurosurgery. Spine·Alejandro Urban-BaezaAlejandro Reyes-Sánchez
Jan 15, 2015·The American Journal of Psychiatry·Jennifer L GordonKatherine L Wisner
Feb 3, 2015·Psychiatria polska·Edward PietrzykBeata Wożakowska-Kapłon
Jun 4, 2015·Biological Psychiatry·Rebecca A BrachmanChristine A Denny
Jun 10, 2016·Regional Anesthesia and Pain Medicine·Eric S SchwenkRichard H Epstein
Nov 12, 2016·Mayo Clinic Proceedings·Bayard R WilsonClark C Chen
Nov 15, 2016·Journal of Affective Disorders·Steven J PennybakerCarlos A Zarate
Mar 18, 2017·Nature Reviews. Drug Discovery·James W MurroughSanjay J Mathew
Mar 28, 2017·Neuroscience and Biobehavioral Reviews·Francesco BartoliGiuseppe Carrà
Mar 7, 2018·Current Biology : CB·George A Mashour, Max B Kelz
Mar 28, 2018·Translational Psychiatry·Christian Clemm von HohenbergAlexander Sartorius
Jun 1, 2018·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Marieke A VisserHenry B Ellis
Oct 3, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Hyo Geun ChoiChang Myeon Song
Oct 26, 2018·European Archives of Psychiatry and Clinical Neuroscience·Meng LiMartin Walter
Apr 18, 2019·The Journal of Clinical Psychiatry·Joshua D RosenblatRoger S McIntyre

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Citations

May 4, 2021·Current Opinion in Anaesthesiology·David B Guthrie, Deborah C Richman
May 31, 2021·Current Opinion in Anaesthesiology·Sabine Himmelseher, Eberhard F Kochs

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Methods Mentioned

BETA
cesarean section
coronary artery bypass

Software Mentioned

Review Manager

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