Can kinomics and proteomics bridge the gap between pediatric cancers and newly designed kinase inhibitors?

Cellular and Molecular Life Sciences : CMLS
Naomi E van der SligteEveline S J M de Bont

Abstract

The introduction of kinase inhibitors in cancer medicine has transformed chronic myeloid leukemia from a fatal disease into a leukemia subtype with a favorable prognosis by interfering with the constitutively active kinase BCR-ABL. This success story has resulted in the development of multiple kinase inhibitors. We are currently facing significant limitations in implementing these kinase inhibitors into the clinic for the treatment of pediatric malignancies. As many hallmarks of cancer are known to be regulated by intracellular protein signaling networks, we suggest focusing on these networks to improve the implementation of kinase inhibitors. This viewpoint will provide a short overview of currently used strategies for the implementation of kinase inhibitors as well as reasons why kinase inhibitors have unfortunately not yet been widely used for the treatment of pediatric cancers. We argue that by using a future personalized medicine strategy combining kinomics, proteomics, and drug screen approaches, the gap between pediatric cancers and the use of kinase inhibitors may be bridged.

References

Jan 27, 2000·Cell·D Hanahan, R A Weinberg
May 18, 2001·Nature·P Blume-Jensen, T Hunter
Feb 26, 2004·Blood·Bruno Calabretta, Danilo Perrotti
Aug 3, 2004·Nature Medicine·Bert Vogelstein, Kenneth W Kinzler
Sep 1, 2004·Lancet·Patrina H Y CaldwellJonathan C Craig
Jul 31, 2007·Lancet·Rüdiger HehlmannUNKNOWN European LeukemiaNet
Apr 15, 2008·Nature·Charles G MullighanJames R Downing
May 7, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lecia V SequistThomas J Lynch
Nov 1, 2008·Cancer Research·Vincent T DeVita, Edward Chu
May 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey W TynerBrian J Druker
Jul 2, 2009·Cancer Research·Arend H SikkemaEveline S J M de Bont
Nov 17, 2009·Proceedings of the National Academy of Sciences of the United States of America·Caroline M EmeryLevi A Garraway
Sep 8, 2010·The New England Journal of Medicine·Keith T FlahertyPaul B Chapman
Oct 1, 2010·Nature·J S de Bono, Alan Ashworth
Dec 8, 2010·Nature Reviews. Clinical Oncology·Alberto OcanaIan F Tannock
Dec 21, 2010·Current Opinion in Pediatrics·Kathryn G Roberts, Charles G Mullighan
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Jun 7, 2011·Critical Reviews in Oncology/hematology·Arend H SikkemaEveline S J M de Bont
Mar 31, 2012·Nature·C Glenn Begley, Lee M Ellis
Jun 23, 2012·Neuro-oncology·Arend H SikkemaEveline S J M de Bont
Oct 2, 2012·Metabolism: Clinical and Experimental·Johanne Tremblay, Pavel Hamet
Dec 20, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Muling MaoScott Kopetz
Jan 5, 2013·Advances in Experimental Medicine and Biology·Chandrika Gowda, Sinisa Dovat
Jan 19, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gilles VassalBruce Morland
Mar 30, 2013·Science·Bert VogelsteinKenneth W Kinzler
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Katherine A JanewayMarian H Harris
May 3, 2013·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkGreg Eley
Dec 20, 2013·Lancet·Douglas Hanahan
Feb 4, 2014·CA: a Cancer Journal for Clinicians·Elizabeth WardAhmedin Jemal
Apr 22, 2014·Expert Opinion on Pharmacotherapy·Gabriele MinutiFederico Cappuzzo
Jul 6, 2014·Science Translational Medicine·Jeffrey W Tyner
Dec 2, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Gilles VassalHeinz Zwierzina

❮ Previous
Next ❯

Citations

Oct 14, 2017·Critical Reviews in Clinical Laboratory Sciences·Lampros DimitrakopoulosGeorge S Charames
Aug 9, 2016·Expert Review of Proteomics·Gavino FaaMassimo Castagnola

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
proteome profiling

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Cancer -Omics

A variety of different high-throughput technologies can be used to identify the complete catalog of changes that characterize the molecular profile of cohorts of tumor samples. Discover the latest insights gained from cancer 'omics' in this feed.