Can KRAS and BRAF mutations limit the benefit of liver resection in metastatic colorectal cancer patients? A systematic review and meta-analysis

Critical Reviews in Oncology/hematology
Francesco PassigliaAntonio Russo

Abstract

Clinical trials investigated the potential role of both KRAS and BRAF mutations, as prognostic biomarkers, in colorectal cancer (CRC) patients who underwent surgical treatment of CRC-related liver metastases (CLM), showing conflicting results. This meta-analysis aims to review all the studies reporting survival outcomes (recurrence free survival (RFS), and/or overall survival (OS)) of patients undergoing resection of CLM, stratified according to KRAS and/or BRAF mutation status. Data from all published studies reporting survival outcomes (RFS and/or OS) of CRC patients who received resection of CLM, stratified by KRAS and/or BRAF mutation status were collected, according to the PRISMA guidelines. Pooled HRs were calculated for both the OS and/or RFS. Seven eligible trials (1403 patients) were included. Pooled analysis showed that KRAS mutations predicted a significantly worse both RFS (HR: 1.65; 95% CI: 1.23-2.21) and OS (HR: 1.86; 95% CI: 1.51-2.30) in patients who underwent surgical resection of CLM. BRAF mutations were also associated with a significantly worse OS (HR: 3.90; 95% CI: 1.96-7.73) in this subgroup of patients. This meta-analysis suggests both KRAS and BRAF mutations as poor, prognostic biomarkers, associated wit...Continue Reading

References

Aug 19, 1992·International Journal of Cancer. Journal International Du Cancer·B SuchyH M Rabes
Jan 1, 1995·Archives of Surgery·W V KastrinakisI C Summerhayes
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·C P WebbG F Vande Woude
May 30, 2002·Annals of Surgery·Michael A ChotiJohn L Cameron
Apr 14, 2005·Molecular Cancer Therapeutics·Srikala S SridharLillian L Siu
Nov 13, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Federica Di NicolantonioAlberto Bardelli
Dec 31, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J Randolph HechtRafael G Amado
May 28, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Scott KopetzRobert R McWilliams
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Susan D RichmanPhilip Quirke
Feb 23, 2010·International Journal of Surgery·David MoherUNKNOWN PRISMA Group
Apr 24, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jolien TolIris D Nagtegaal
Sep 15, 2010·Annals of Surgical Oncology·Doran KsienskiHagen Kennecke
Jan 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jeanne TieOliver M Sieber
Jun 8, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Timothy J PriceNiall C Tebbutt
Feb 15, 2012·Journal of Surgical Oncology·Hao-Wei TengShung-Haur Yang
Mar 27, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carsten BokemeyerClaus-Henning Köhne
Jun 6, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Efsevia VakianiDavid B Solit
Jun 27, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sabine TejparEric Van Cutsem
Oct 3, 2012·The British Journal of Surgery·S StremitzerT Gruenberger
Feb 28, 2013·Expert Opinion on Biological Therapy·Giuseppe BronteAntonio Russo
Jul 16, 2013·Expert Opinion on Therapeutic Targets·Christian RolfoMarc Peeters
Sep 13, 2013·The New England Journal of Medicine·Jean-Yves DouillardScott D Patterson
Mar 29, 2014·Expert Opinion on Biological Therapy·Giuseppe BronteAntonio Russo
Jun 20, 2014·Journal of Cancer Research and Clinical Oncology·Tae Sung AhnMoo-Jun Baek
Jun 25, 2014·Expert Review of Gastroenterology & Hepatology·Christian RolfoMarc Peeters
Sep 25, 2014·Expert Opinion on Biological Therapy·Giuseppe BronteAntonio Russo
Jan 22, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Eric Van CutsemFortunato Ciardiello
May 6, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C BokemeyerS Tejpar

❮ Previous
Next ❯

Citations

Mar 2, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 27, 2018·The British Journal of Surgery·S YamashitaJ-N Vauthey
Mar 28, 2017·World Journal of Gastrointestinal Oncology·Torhild Veen, Kjetil Søreide
Apr 13, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Carlotta BarbonMatthew J Weiss
Oct 5, 2018·International Journal of Molecular Sciences·Gianluca LopezAlessandro Del Gobbo
Jan 20, 2019·Journal of Clinical Medicine·Joon-Hyop LeeHeejoon Chae
Feb 20, 2019·Journal of Surgical Oncology·Georgios A MargonisMatthew J Weiss
May 23, 2019·CA: a Cancer Journal for Clinicians·Wafik S El-DeiryJohn L Marshall
Jul 11, 2019·Journal of Surgical Oncology·Erin M CorsiniMara B Antonoff
Mar 25, 2020·The Cancer Journal·Kevin J Barnum, Sarah A Weiss
Jun 5, 2018·Annals of Gastroenterological Surgery·Eiji OkiYoshihiko Maehara
Jun 4, 2020·Acta Cirúrgica Brasileira·Raphael Leonardo Cunha de AraujoJacques Marescaux
May 6, 2020·Cardiovascular and Interventional Radiology·Alexander DabrowieckiNima Kokabi
Mar 8, 2019·World Journal of Gastrointestinal Surgery·Raphael Lc Araujo, Marcelo M Linhares
Sep 28, 2017·World Journal of Surgery·Jocelyn BellierStéphanie Truant
Oct 26, 2016·Journal of Surgical Oncology·Raphael L C AraujoYuman Fong
Nov 22, 2018·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·P ReijonenA Nordin
Mar 3, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Krishan R JethwaChristopher L Hallemeier
Jul 18, 2020·Bulletin du cancer·Astrid LièvreGérard Lledo
Jun 9, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Laurence GauJohan Gagnière
Aug 3, 2021·Annals of Gastroenterological Surgery·Markus K Diener, Stefan Fichtner-Feigl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.