Can locoregional treatment of the primary tumor improve outcomes for women with stage IV breast cancer at diagnosis?

International Journal of Radiation Oncology, Biology, Physics
David H A NguyenMary Lesperance

Abstract

To examine the effect of locoregional treatment (LRT) of the primary tumor on survival in patients with Stage IV breast cancer at diagnosis. The study cohort comprised 733 women referred to the British Columbia Cancer Agency between 1996 and 2005 with newly diagnosed clinical or pathologic M1 breast cancer. Tumor and treatment characteristics, overall survival (OS), and locoregional progression-free survival were compared between patients treated with (n = 378) and without (n = 355) LRT of the primary disease. Multivariable analysis was performed with Cox regression modeling. The median follow-up time was 1.9 years. LRT consisted of surgery alone in 67% of patients, radiotherapy alone in 22%, and both in 11%. LRT was used more commonly in women with age <50 years, Eastern Cooperative Oncology Group (ECOG) performance status 0-1, Stage T1-2 tumors, N0-1 disease, limited M1 burden, and asymptomatic M1 disease (all p < 0.05). Systemic therapy was used in 92% of patients who underwent LRT and 85% of patients who did not. In patients treated with LRT compared with those without LRT, the 5-year OS rates were 21% vs. 14% (p < 0.001), and the rates of locoregional progression-free survival were 72% vs. 46% (p < 0.001). Among 378 patien...Continue Reading

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Citations

Apr 6, 2012·Annals of Surgical Oncology·David H A NguyenCheryl Alexander
Sep 23, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F CardosoE Winer
Feb 18, 2016·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Chikako YamauchiHirofumi Mukai
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Jan 28, 2017·International Journal of Radiation Oncology, Biology, Physics·Pauline T Truong
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May 4, 2018·South Asian Journal of Cancer·S P SomsekharR Koul
Dec 16, 2020·Clinical and Translational Radiation Oncology·Claire BosackiNicolas Magné

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