Can lycopene be delivered into semen via prostasomes? In vitro incorporation and retention studies

International Journal of Andrology
A GoyalA J Cooper

Abstract

Lycopene (C(40) H(56)) is a highly lipophilic antioxidant found in human semen in nanomolar concentrations. It has been shown to be one of the most potent carotenoid antioxidant in various human studies. Prostasomes are organelles secreted by glandular prostatic epithelial cells and are known to play an important role in fertility and prostate cancer. They are also known to possess antioxidant activity and aid the functioning of sperm. We studied the ability of these vesicles to adsorb and retain lycopene into their rich lipid environment in vitro. High-performance liquid chromatography analysis confirmed micrograms of lycopene per milligram of prostasomal protein. In view of the prostasomes' lipid-rich nature it is highly likely that these organelles act as delivery vehicles for this highly lipophilic antioxidant substance into human semen.

References

Jan 1, 1990·Archives of Andrology·I Olsson, G Ronquist
Nov 1, 1989·Archives of Biochemistry and Biophysics·P Di MascioH Sies
Sep 9, 1985·Biochimica Et Biophysica Acta·G Ronquist, I Brody
Jan 1, 1982·Urological Research·B Stegmayr, G Ronquist
Dec 9, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·C B LaurellG Rannevik
Oct 1, 1996·The American Journal of Clinical Nutrition·K J YeumR M Russell
Jan 1, 1997·The Journal of Membrane Biology·G ArientiC A Palmerini
Feb 20, 1997·International Journal of Cancer. Journal International Du Cancer·T C Bakker SchutC G Figdor
Apr 17, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·D TalwarD S O'Reilly
Aug 14, 1998·Molecular Human Reproduction·F SaezG Grizard
Oct 24, 1998·Archives of Biochemistry and Biophysics·G ArientiC A Palmerini
May 13, 1999·Biology of the Cell·G ArientiC A Palmerini
Nov 11, 1999·Clinica Chimica Acta; International Journal of Clinical Chemistry·G ArientiC A Palmerini
May 15, 2003·The Prostate·Angelita G UtlegBiaoyang Lin
Aug 6, 2003·International Urology and Nephrology·Narmada P Gupta, Rajeev Kumar

❮ Previous
Next ❯

Citations

May 9, 2007·BJU International·Anuj GoyalAlan J Cooper
Sep 19, 2006·BJU International·Anuj GoyalAlan J Cooper
Jul 6, 2015·Micron : the International Research and Review Journal for Microscopy·S Goericke-PeschA Wehrend
Sep 8, 2016·Journal of Animal Science and Biotechnology·Eva TvrdáNorbert Lukáč

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.