Can morphometric analysis of the fallopian tube fimbria predict the presence of uterine papillary serous carcinoma (UPSC)?

PloS One
Amnon AmitGeula Klorin

Abstract

Uterine serous papillary carcinoma (UPSC) is an aggressive tumor, often diagnosed as a metastatic disease and characterized by a high recurrence rate and poor prognosis. UPSC represents a distinct subtype of endometrial cancer which is different in clinical and pathological behaviors from endometrioid endometrial carcinoma (EEC) and resembles more to serous ovarian carcinoma. Since tumors of serous papillary of the ovary are hypothesized to stem from cells of the fallopian tube's fimbria, we hypothesized that UPSC may also origin in the fallopian tubes. In our previous study, using a novel method of computerized morphometry of the fimbrial epithelium we have found significant differences between fimbriae of healthy women and serous ovarian cancer patients. In this study we showed the presence of morphologic differences between twenty-four fimbriae from healthy women, and twenty six fimbriae from uterus cancer (13 from UPSC patients and 13 from EEC patients). All fimbriae reported by the pathologist as "normal" were subjected to a computerized histomorphometric analysis. Two-step method of computerized histomorphometry, i.e. Fast Fourier transformation (FFT) followed by a co-occurrence matrix analysis and an additional analysis ...Continue Reading

References

Jan 1, 1989·Virchows Archiv. A, Pathological Anatomy and Histopathology·S NakajoE Tahara
Feb 1, 1983·Gynecologic Oncology·J V Bokhman
Oct 3, 2006·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·J A VillellaD Hershman
Oct 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jonathan L Hecht, George L Mutter
Nov 1, 2006·Laboratory Investigation; a Journal of Technical Methods and Pathology·Edmond SaboMurray B Resnick
Apr 7, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·William Creasman
Jun 2, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Elke A JarboeMarisa R Nucci
Jun 23, 2009·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Patricia A ShawHeather Begley
Jul 16, 2010·Developmental Cell·Mikala EgebladZena Werb
Jan 13, 2012·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Sep 25, 2012·Gynecologic Oncology·Marcela G del CarmenJohn O Schorge
Dec 18, 2012·Histopathology·Russell VangRobert J Kurman
Oct 23, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·N ColomboUNKNOWN ESMO Guidelines Working Group
Dec 5, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Mary C TolcherSean C Dowdy
Sep 2, 2017·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Amnon AmitGeula Klorin

❮ Previous
Next ❯

Citations

May 2, 2021·Microscopy Research and Technique·Geula KlorinEdmond Sabo

❮ Previous
Next ❯

Methods Mentioned

BETA
hysterectomy

Software Mentioned

Statistical Package for the Social Sciences
Image Pro Plus

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Amnon AmitGeula Klorin
Zhonghua bing li xue za zhi Chinese journal of pathology
Jia WenQiu-jing Song
© 2022 Meta ULC. All rights reserved