PMID: 7009784Feb 1, 1981Paper

Can mother-infant interaction produce vulnerability to schizophrenia?

The Journal of Nervous and Mental Disease
E B Brody

Abstract

Schizophrenia is regarded as a final common behavioral syndrome which may be arrived at though a variety of routes. Even with a probably genotype, environmental influence seems necessary for the phenotype to appear. The problem concerns the likelihood of an early experience-induced sequence of events within the person of infant and later adult vs. a continuing pathogenic environment. Either may or may not interact with a continuing genic factor(s) as a source of vulnerability. Vulnerability is here, then, viewed as epigenetically evolving via individual-environment transactions throughout life (although with major impacts from conception through adolescence). At any point, therapeutic intervention may preclude or minimize the actualization of the pathogenic potential. It may begin during pregnancy, with attention to such factors as diet, drugs, physical stress, and illness, influencing fetal development and obstetrical manipulations and the birth process. All influence earliest mother-infant interaction from the point of view both of the infant's evocation of maternal behavior and maternal responsivity. Therapeutic interventions also include attention to the multigenerational context of earliest interaction, with special refere...Continue Reading

Citations

Jan 1, 1984·Neuroscience and Biobehavioral Reviews·J L Haracz
Oct 16, 2012·European Psychiatry : the Journal of the Association of European Psychiatrists·S G GiakoumakiP Bitsios
Feb 9, 2002·Developmental Psychobiology·Melissa Hunsley, Evelyn B Thoman
May 30, 2013·Molecular Pharmacology·Jordan MarroccoFerdinando Nicoletti
Jan 1, 1990·The Journal of the American Academy of Psychoanalysis·D C Fort

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