Can oligodendrocyte precursor cells be a therapeutic target for mitigating cognitive decline in cerebrovascular disease?

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Ken Arai

Abstract

Oligodendrocyte precursor cells (OPCs) give rise to mature myelin-forming oligodendrocytes during white matter development. In adult brains, some populations of OPCs remain to renew oligodendrocyte pools and myelin. Two recent studies highlight the importance of OPCs in white matter homeostasis. Genetic tracing studies suggest that age-related decline in OPCs may contribute to diminished myelin renewal and memory deficits in mouse models. Single cell transcriptomics and imaging may now define specific subsets of OPCs involved in process elaboration, motility and myelination. These advances raise the possibility of pursuing OPCs as novel therapeutic targets for vascular cognitive impairment.

References

Mar 20, 2012·Nature Neuroscience·Robert J ZatorreHeidi Johansen-Berg
Jul 25, 2013·Stroke; a Journal of Cerebral Circulation·Nobukazu MiyamotoKen Arai
Nov 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Leonie LampePierre-Louis Bazin
Nov 7, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·William A BanksYoichi Morofuji
Sep 12, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Murielle G KlugeFrederick R Walker
Sep 17, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mustafa Balkaya, Sunghee Cho
Oct 28, 2019·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Carla CirilloIsabelle Loubinoux

❮ Previous
Next ❯

Citations

Dec 15, 2020·CNS Neuroscience & Therapeutics·Akihiro ShindoKen Arai
Apr 30, 2021·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Akiko NishiyamaFriederike Pfeiffer
May 11, 2021·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Ken Arai, Eng H Lo
Jul 6, 2021·Frontiers in Cell and Developmental Biology·Hajime TakaseKen Arai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.