Can patients at risk for persistent negative symptoms be identified during their first episode of psychosis?

The Journal of Nervous and Mental Disease
A K MallaRaj Haricharan

Abstract

Patients with schizophrenia who show persistent negative symptoms are an important subgroup, but they are difficult to identify early in the course of illness. The objective of this study was to examine characteristics that discriminate between first-episode psychosis (FEP) patients in whom primary negative symptoms did or did not persist after 1 year of treatment. Patients with a DSM-IV diagnosis of FEP whose primary negative symptoms did (N = 36) or did not (N = 35) persist at 1 year were contrasted on their baseline and 1-year characteristics. Results showed that patients with persistent primary negative symptoms (N = 36) had a significantly longer duration of untreated psychosis (p < .005), worse premorbid adjustment during early (p < .001) and late adolescence (p < .01), and a higher level of affective flattening (p < .01) at initial presentation compared with patients with transitory primary negative symptoms. The former group also showed significantly lower remission rates at 1 year (p < .001). Multiple regression analysis confirmed the independent contribution of duration of untreated psychosis, premorbid adjustment, and affective flattening at baseline to the patients' likelihood of developing persistent negative sympt...Continue Reading

References

Feb 1, 1978·The American Journal of Psychiatry·R Abrams, M A Taylor
Apr 1, 1977·Perceptual and Motor Skills·D M Gronwall
Sep 1, 1992·The British Journal of Psychiatry : the Journal of Mental Science·K W Brown, T White
Sep 1, 1992·Psychiatry Research·J A HustedW G Iacono
Jan 1, 1991·Schizophrenia Bulletin·K T MueserR L Morrison
Mar 1, 1991·The British Journal of Psychiatry : the Journal of Mental Science·P F Liddle, D L Morris
Jul 1, 1990·Schizophrenia Research·D AddingtonB Schissel
Nov 1, 1990·Psychological Medicine·P J McKennaA D Baddeley
Nov 1, 1989·Journal of Abnormal Psychology·H E Spohn, M E Strauss
Jan 1, 1985·Schizophrenia Bulletin·N C Andreasen
May 1, 1988·The American Journal of Psychiatry·W T CarpenterA M Wagman
Aug 1, 1980·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J Gaito
Jan 1, 1982·Schizophrenia Bulletin·H E Cannon-SpoorR J Wyatt
Oct 1, 1994·The American Journal of Psychiatry·D I MayerhoffJ A Lieberman
Jan 1, 1994·Schizophrenia Bulletin·B A Cornblatt, J G Keilp
Sep 1, 1995·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·A K Malla
Apr 1, 1996·The American Journal of Psychiatry·S R SzymanskiR E Gur
Mar 1, 1996·The American Journal of Psychiatry·M F Green
Nov 1, 1995·International Clinical Psychopharmacology·J CarmanA Vangeneugden
Nov 15, 1996·Schizophrenia Research·B KirkpatrickE Bromet
Feb 1, 1997·The British Journal of Psychiatry : the Journal of Mental Science·R M NormanL Cortese
Sep 12, 1998·The American Journal of Psychiatry·B C HoN C Andreasen
Sep 10, 1999·Acta Psychiatrica Scandinavica·H HäfnerW an der Heiden
Jan 13, 2001·Comprehensive Psychiatry·R PenadésM Salamero
Feb 15, 2001·Archives of General Psychiatry·B KirkpatrickW T Carpenter
Oct 3, 2001·The British Journal of Psychiatry : the Journal of Mental Science·R M NormanA K Malla
Apr 13, 2002·Schizophrenia Research·G P AmmingerP D McGorry
Jun 13, 2002·Acta Psychiatrica Scandinavica·Ashok K MallaRashid Ahmed

❮ Previous
Next ❯

Citations

Feb 12, 2008·Neuroscience and Behavioral Physiology·I S LebedevaA N Barkhatova
Feb 4, 2009·Psychological Medicine·C WhiteS Lewis
Sep 4, 2008·Journal of the International Neuropsychological Society : JINS·Kathryn E GreenwoodTil Wykes
Oct 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Michael BodnarMartin Lepage
Sep 2, 2008·The British Journal of Psychiatry : the Journal of Mental Science·Thomas R E BarnesEileen M Joyce
Aug 21, 2013·L'Encéphale·H YazbekD Capdevielle
Dec 12, 2012·BMC Psychiatry·Cindy L HovingtonMartin Lepage
Aug 12, 2014·Schizophrenia Research·Alp Üçok, Ceylan Ergül
Dec 2, 2009·Schizophrenia Research·Ann FaerdenIngrid Melle
Oct 20, 2009·Journal of Psychiatric Research·P Fusar-PoliUNKNOWN OASIS Team
Apr 9, 2008·Psychiatry Research·Brian J JonesJoseph A McFalls
Mar 21, 2007·Schizophrenia Research·Christine SchmaelMarcella Rietschel
Nov 30, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·Bernard J GallagherAnthony M Pisa
Oct 19, 2010·CNS Neuroscience & Therapeutics·Max Jean-Lon ChenJohn H Gruzelier
Jan 15, 2015·Early Intervention in Psychiatry·John LyneAshok Malla
Mar 5, 2010·Early Intervention in Psychiatry·Lisa BuchyMartin Lepage
Jun 10, 2006·European Psychiatry : the Journal of the Association of European Psychiatrists·B J GallagherA M Pisa
Apr 25, 2016·European Archives of Psychiatry and Clinical Neuroscience·Wolfram An der HeidenHeinz Häfner
Jun 1, 2012·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Silvana GalderisiUNKNOWN Eufest Study Group
Nov 28, 2013·Clinical Schizophrenia & Related Psychoses·Bernard J GallagherMariana Pardes
May 27, 2014·Frontiers in Behavioral Neuroscience·Yuko HiguchiTomiki Sumiyoshi
Dec 10, 2013·European Psychiatry : the Journal of the Association of European Psychiatrists·R K R SalokangasUNKNOWN EPOS group
Jun 1, 2016·Schizophrenia Research·Armida MucciSilvana Galderisi
Jun 10, 2016·Psychiatry Research·Wing Chung ChangEric Yu Hai Chen
Feb 5, 2016·The International Journal of Social Psychiatry·Bernard J Gallagher, Brian J Jones
Oct 11, 2014·The International Journal of Social Psychiatry·Kristian L ToftegaardPovl Munk-Jørgensen
Jul 14, 2017·The International Journal of Social Psychiatry·Bernard J Gallagher, Brian J Jones

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.