Can power Doppler ultrasound of the entheses help in classifying recent axial spondyloarthritis? Data from the DESIR cohort

RMD Open
Cécile PoulainPascal Claudepierre

Abstract

Early diagnosis of axial spondyloarthritis (axSpA) remains a challenge due to the lack of specificity of clinical symptoms and variable prevalence of axial imaging findings permitting a definite diagnosis. Power Doppler ultrasonography (PDUS) of the entheses has demonstrated to be a potential useful tool for the classification and diagnostic management of early SpA independently of the phenotype. To assess the classification value (sensitivity and specificity) of PDUS-defined enthesitis for identifying patients fulfilling Assessment of SpondyloArthritis international Society (ASAS) classification criteria for axSpA (ASAS+) in patients with recent inflammatory back pain (IBP) (the DESIR (DEvenir des Spondylarthropathies Indifférenciées Récentes) cohort). Baseline PDUS was performed at eight entheseal sites, and PDUS enthesitis was defined by the presence of vascularisation at entheseal insertion. 402 patients from the DESIR cohort underwent a PDUS evaluation. PDUS enthesitis was detected in 58 (14.4%) patients of whom 40 (14.2%) belonged to the ASAS+ patients and 18 (17%) to the ASAS- patients. The sensitivity of PDUS enthesitis was 13.9% and the specificity was 83.5%, with a positive predictive value of 69% and 26.8% of negativ...Continue Reading

References

Mar 31, 2004·Annals of the Rheumatic Diseases·M C W CreemersP L C M van Riel
Apr 9, 2005·Arthritis and Rheumatism·Martin RudwaleitJoachim Sieper
Apr 9, 2008·Annals of the Rheumatic Diseases·E de MiguelE Martín-Mola
Jan 30, 2009·Arthritis and Rheumatism·Floranne C WilsonHilal Maradit Kremers
Sep 3, 2010·The Journal of Rheumatology·Esperanza NaredoUNKNOWN Ultrasound Group of the Spanish Society of Rheumatology
May 19, 2011·Annals of the Rheumatic Diseases·Maria Antonietta D'AgostinoMaxime Breban
Nov 19, 2011·Arthritis Research & Therapy·Frédérique GandjbakhchUNKNOWN OMERACT Ultrasound Task Force
Oct 24, 2013·Arthritis Care & Research·L TerslevUNKNOWN Outcome Measures in Rheumatology Ultrasound Task Force

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Citations

Sep 4, 2021·Ultraschall in der Medizin : Organ der Deutschen Gesellschaft für Ultraschall in der Medizin, [der] Österreichischen Gesellschaft für Ultraschall in der Medizin, [der] Schweizerischen Gesellschaft für Ultraschall in Medizin und Biologie·Daniela FodorEsperanza Naredo

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Clinical Trials Mentioned

NCT01648907

Software Mentioned

R
SAS

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