Can predictors of response to NSAIDs be identified in patients with acute low back pain?

The Clinical Journal of Pain
Mark J HancockReece A Davies

Abstract

The aim of this study was to determine whether certain patient characteristics could identify people with acute low back pain who were more likely to respond to nonsteroidal anti-inflammatory drugs (NSAIDs), when administered in combination with paracetamol. This study involved a secondary analysis of a randomized controlled trial investigating the efficacy of diclofenac in 239 patients presenting to general practitioners for acute low back pain. All patients received advice to "stay active" and take regular paracetamol and then were randomized to receive either diclofenac (50 mg twice daily) or placebo. The primary outcome was days to recovery from pain. The ability of 14 patient characteristics to identify those who respond best to diclofenac was assessed using interaction terms in Cox regression models. Most of the 14 baseline characteristics investigated were uninformative in identifying those who respond best to diclofenac when added to paracetamol. Patients' sex and levels of fear regarding movement and pain were both independent statistically significant predictors of response to NSAIDs for one definition of recovery but not for the other. The interaction between fear avoidance (physical activity) and NSAIDs treatment wa...Continue Reading

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Citations

Nov 24, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Charles SheetsChris Maher
Jul 24, 2010·BMC Musculoskeletal Disorders·Christopher M WilliamsChung-Wei Christine Lin
Mar 13, 2014·The Spine Journal : Official Journal of the North American Spine Society·Maria M WertliFlorian Brunner
Apr 8, 2020·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Aleksandra Bitenc-JasiejkoDanuta Lietz-Kijak
Oct 8, 2020·Journal of Women's Health·Chen X ChenJ Dennis Fortenberry
Dec 9, 2020·Behavioural Pharmacology·Rebecca M CraftStevie C Britch

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