Can prophylactic argon plasma coagulation reduce delayed post-papillectomy bleeding? A prospective multicenter trial.

Journal of Gastroenterology and Hepatology
Jae Kook YangSang-Heum Park

Abstract

Endoscopic post-papillectomy bleeding occurs in 3% to 20% of the cases, and delayed bleeding is also problematic. However, there is no consensus on how to reduce delayed post-papillectomy bleeding. The aim of this study was to evaluate the efficacy of prophylactic argon plasma coagulation (APC) to minimize delayed bleeding and reduce the persistence of residual tumors after endoscopic papillectomy. In a prospective pilot study of patients with benign ampullary tumors, the prophylactic APC group underwent APC at the resection margin following a conventional snaring papillectomy. Then, 24 h later after the papillectomy, all patients underwent a follow-up duodenoscopy to identify post-papillectomy bleeding and were followed up until 12 months. The main outcomes were the delayed (≥24 h) post-papillectomy bleeding rate and the tumor persistence rate. The delayed post-papillectomy bleeding rate was 30.8% (8/26) in the prophylactic APC group and 21.4% (6/28) in the non-APC group (P = 0.434). The post-procedure pancreatitis rates were 23.1% (6/26) and 35.7% (10/28), respectively (P = 0.310). The rate of tumor persistence did not differ between the two groups at 1 month (12.5% vs 7.4%, P = 0.656), 3 months (4.2% vs 3.7%, P = 1.00), 6 mo...Continue Reading

References

Jul 1, 1992·Gastrointestinal Endoscopy·A Van GossumM Cremer
Mar 1, 1993·Gastrointestinal Endoscopy·K F BinmoellerN Soehendra
Apr 24, 2001·Endoscopy·Z ZádorováJ Hajer
Jul 30, 2002·Gastrointestinal Endoscopy·Ian D NortonMaurits J Wiersema
Mar 4, 2003·Gastrointestinal Endoscopy·Ali FazelJoseph E Geenen
Jan 28, 2004·Gastrointestinal Endoscopy·Marc F CatalanoDouglas A Howell
Sep 16, 2004·Journal of Hepato-biliary-pancreatic Surgery·Jean P ChartonHorst Neuhaus
Nov 24, 2004·Gastrointestinal Endoscopy·Chi-Liang ChengGlen A Lehman
Dec 2, 2004·The American Journal of Gastroenterology·Michel KahalehPaul Yeaton
Jan 24, 2006·Gastrointestinal Endoscopy·Jimin Han, Myung-Hwan Kim
Aug 8, 2006·Current Opinion in Gastroenterology·Sydney A Wilson, Douglas K Rex
Jun 27, 2007·Gastrointestinal Endoscopy·Federico IacopiniGuido Costamagna
Apr 24, 2009·Gastrointestinal Endoscopy·Chang Kyun LeeSun-Joo Kim
Mar 2, 2010·Gastrointestinal Endoscopy·Peter B CottonJohn J Vargo
Jul 3, 2010·Journal of Gastroenterology and Hepatology·Fouad HarrasLoai Mansour
Sep 10, 2013·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Eric SwansonAasma Shaukat
Mar 4, 2014·World Journal of Gastroenterology : WJG·Giovanni D De Palma
Aug 22, 2015·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Hisanobu DeguchiMasao Ichinose
Dec 2, 2015·Gastrointestinal Endoscopy·UNKNOWN ASGE STANDARDS OF PRACTICE COMMITTEEJohn M DeWitt
Dec 31, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Kwangwoo NamSeunghee Baek
Nov 14, 2018·Surgical Endoscopy·Shuling LiWen Li
Apr 16, 2019·World Journal of Gastroenterology : WJG·Qing-Hua ZhongLei Wang
Jun 22, 2019·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Eisuke IwasakiTakanori Kanai
Sep 19, 2019·Clinical Endoscopy·Aditya Gutta, Mark A Gromski

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.