Can Rectal Diclofenac Prevent Post Endoscopic Retrograde Cholangiopancreatography Pancreatitis?

Digestive Diseases and Sciences
Guan Way LuaJayaram Menon

Abstract

Non steroidal anti-inflammatory drugs (NSAIDs) have been shown to reduce the incidence of post endoscopic retrograde cholangiopancreatography pancreatitis (PEP). There were various trials using different routes and dosages of NSAIDs but meta-analysis revealed inconsistent results. The aims of this study were to determine the efficacy of rectal diclofenac in preventing PEP and to evaluate any adverse events. This was a randomized, open-label, two-arm, prospective clinical trial. Only patients at high risk of developing PEP were recruited. They received 100 mg rectal diclofenac or no intervention immediately after ERCP. The patients were reviewed 30 days after discharge to evaluate any adverse event. Among 144 recruited patients, 69 (47.9%) received diclofenac and 75 (52.1%) had no intervention. Eleven patients (7.6%) developed PEP, in which seven were from the diclofenac group and four were in the control group. Eight cases of PEP (5.5%) were mild and three cases (2.1%) were moderate. The differences in pancreatitis incidence and severity between both groups were not statistically significant. There were 11 adverse events reported. Clinically significant bleeding happened in four patients (2.8%): one from the diclofenac group an...Continue Reading

References

May 1, 1991·Gastrointestinal Endoscopy·P B CottonN Nickl
May 1, 1968·Annals of Surgery·W S McCuneH Moscovitz
Aug 1, 1997·Scandinavian Journal of Clinical and Laboratory Investigation·A MäkeläT Schröder
Mar 4, 2003·Gastrointestinal Endoscopy·Ali FazelJoseph E Geenen
Mar 16, 2007·The American Journal of Gastroenterology·Rasoul SotoudehmaneshMehdi Nouraie
Aug 9, 2007·Journal of Gastroenterology and Hepatology·Manouchehr KhoshbatenMohammmad Reza Zali
Nov 6, 2007·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Martin L Freeman
Nov 21, 2012·Gastrointestinal Endoscopy·Xiwei DingXiaoping Zou

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Citations

Jun 24, 2015·Digestive Diseases and Sciences·Tilak ShahMitchell L Schubert
Oct 25, 2016·International Journal of Pharmaceutics·Yuanyuan SunLifeng Kang
Apr 5, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Mia RainioLeena Kylänpää
Sep 27, 2018·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Lan LiuHaiyan Jin
May 1, 2021·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Zsolt DubravcsikLászló Madácsy

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