Can resveratrol supplement change inflammatory mediators? A systematic review and meta-analysis on randomized clinical trials

European Journal of Clinical Nutrition
Fahimeh Haghighatdoost, Mitra Hariri

Abstract

Resveratrol as a polyphenolic compound might be able to reduce inflammatory mediators. Change in inflammatory state is identified by the measurement of inflammatory mediators such as interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and C-reactive protein (CRP). The objective of this study is to conduct a systematic review and meta-analysis on randomized controlled trials that assessed the effect of resveratrol on concentration of serum inflammatory mediators. Systematic search was performed up to October 2017 using ISI web of science, PubMed, Scopus, EMBASE, and Google scholar. Weighted mean difference was estimated either by subtracting baseline values from post-intervention value or as the post-intervention values. Fixed effect model was applied to analyze data where heterogeneity was <25%; otherwise, random effects models were applied. The protocol was registered with PROSPERO (No. CRD42018085098). The meta-analysis and systematic review considered 15 trials, involving 658 adults aged 18-75 years. Resveratrol significantly reduced serum CRP levels (WMD = -0.54; 95% CI: -0.78, -0.30; I2 = 77.7%; P < 0.0001), but it had no significant effect on serum IL-6 (WMD = -0.06; 95% CI: -0.27, 0.14; I2 = 62.0%; P = 0.005) and ...Continue Reading

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Citations

Jul 17, 2019·Phytotherapy Research : PTR·Fahimeh Haghighatdoost, Mitra Hariri
Jun 19, 2020·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Carolina Gotera
Jul 30, 2020·Journal of Cellular Physiology·Carmen RodríguezVanesa Martín
Mar 28, 2019·European Journal of Clinical Pharmacology·F HaghighatdoostMitra Hariri
Nov 8, 2018·Nutrients·Alice ChaplinJosep Mercader
Sep 16, 2020·Advances in Nutrition·Mehran RahimlouAmirhossein Ramezani Ahmadi
Nov 22, 2020·Irish Journal of Medical Science·Małgorzata ChudzińskaGrzegorz Grześk
Aug 3, 2021·Oxidative Medicine and Cellular Longevity·Dan LiShixue Cheng

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