PMID: 9437779Jan 23, 1998Paper

Can serology diagnose upper genital tract Chlamydia trachomatis infections? Studies on women with pelvic pain, with or without chlamydial plasmid DNA in endometrial biopsy tissue

Sexually Transmitted Diseases
M CherneskyJ Mahony

Abstract

Upper genital tract chlamydial infections in women are on the increase, and serology might be a convenient tool for diagnosis. Evaluations of this approach are needed in women with or without microbiologic evidence of organisms in the upper genital tract. To compare the results of antibody assays with cervical culture and upper genital tract histopathology in women with pelvic pain and chlamydial plasmid DNA in endometrial biopsies. Chlamydia trachomatis plasmid DNA was detected by polymerase chain reaction (PCR) on extracted deparaffinized endometrial biopsy tissue. Five antichlamydial antibody assays were performed measuring total antibodies or immunoglobulin G (IgG), IgM, and IgA classes on sera from 14 women with plasmid DNA as well as 31 without plasmid DNA. Accepting the presence of plasmid DNA as the gold standard, no single test had total diagnostic accuracy. The best sensitivity and specificity occurred with the following assays: whole inclusion fluorescence (WIF) (100% and 80.6%); microimmunofluorescence IgM (MIF IgM) (78.6% and 93.6%); and heatshock protein-60 enzyme immunoassay (42.9% and 100%). Although recombinant anti-lipopolysaccharide enzyme-linked immunosorbent assays measured anti-chlamydial antibodies in a l...Continue Reading

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Citations

Aug 30, 2008·The Korean journal of laboratory medicine·Tae Yeal ChoiYouhern Ahn
Jul 26, 2011·Journal of Clinical Laboratory Analysis·Rosemary C SheChristine M Litwin
Jun 2, 2007·Infectious Diseases in Obstetrics and Gynecology·A C S MachadoM F C Alves
Sep 18, 2009·Archives of Gynecology and Obstetrics·Elsamawal A El HakimValentine A Akande
Aug 6, 2010·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Rajneesh JhaAruna Mittal
Jan 14, 2016·Sexually Transmitted Diseases·Lisa E ManhartRichard F Catalano
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Sep 18, 2009·International Journal of STD & AIDS·D Taylor-RobinsonP E Munday
Sep 25, 1999·Infection and Immunity·F BetsouJ Orfila

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