Can serum NT-proBNP detect changes of functional capacity in patients with chronic heart failure?

Zeitschrift für Kardiologie
T MeyerW Kindermann

Abstract

Recently, in a cross-sectional study, a correlation of moderate degree was documented between serum BNP (brain natriuretic peptide) and exercise capacity in patients with chronic heart failure (CHF). However, it remains unknown if BNP, which increases in response to high myocardial wall stress, is sufficiently sensitive for changes in exercise capacity during clinical follow-up. To elucidate this, 42 CHF patients were recruited and randomized into a training (T; 58 +/- 10 years; n = 14 NYHA II; n = 5 NYHA III) and a control group (CO; 54 +/- 9, n = 17 NYHA II; n = 6 NYHA III). T carried out 12 weeks of endurance training on a cycle ergometer (4 sessions per week, 45 min duration). Venous blood sampling and cycle ergometry with simultaneous gas exchange measurements were carried out prior to and after the experimental phase. Due to its superior stability during laboratory procedures, NTproBNP was determined instead of BNP. Both proteins are secreted in equimolar amounts and share an identical diagnostic meaning. In both groups, NT-proBNP decreased slightly (T: from 1092 +/- 980 to 805 +/- 724 pg x ml(-1); CO: from 1075 +/- 1068 to 857 +/- 1138 pg x ml(-1); T vs CO: p = 0.65). Anaerobic threshold (AT) as a measure of exercise cap...Continue Reading

Citations

Apr 2, 2005·Zeitschrift für Kardiologie·T MeyerW Kindermann
Feb 27, 2007·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jürgen ScharhagWilfried Kindermann
Jun 14, 2008·Annales de réadaptation et de médecine physique : revue scientifique de la Société française de rééducation fonctionnelle de réadaptation et de médecine physique·J-M CasillasJ-C Eicher
Oct 10, 2007·Journal of Cardiac Failure·Luis E RohdeNadine Clausell
Oct 3, 2008·Biological Research for Nursing·Mei-Kuei TaiLorraine Q Frazier
Jul 20, 2010·Scandinavian Cardiovascular Journal : SCJ·Birgitta Blakstad NilssonIngebjørg Seljeflot

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