Can steroids reverse the severe COVID-19 induced "cytokine storm"?

Journal of Medical Virology
Lykourgos KolilekasMina Gaga

Abstract

Severe coronavirus disease (COVID-19) is characterized by an excessive proinflammatory cytokine storm, resulting in acute lung injury and development of acute respiratory distress syndrome (ARDS). The role of corticosteroids is controversial in severe COVID-19 pneumonia and associated hyper-inflammatory syndrome. We reported a case series of six consecutive COVID-19 patients with severe pneumonia, ARDS and laboratory indices of hyper-inflammatory syndrome. All patients were treated early with a short course of corticosteroids, and clinical outcomes were compared before and after corticosteroids administration. All patients evaded intubation and intensive care admission, ARDS resolved within 11.8 days (median), viral clearance was achieved in four patients within 17.2 days (median), and all patients were discharged from the hospital in 16.8 days (median). Early administration of short course corticosteroids improves clinical outcome of patients with severe COVID-19 pneumonia and evidence of immune hyperreactivity.

References

Mar 4, 2020·Lancet·Lianhan ShangBin Cao
Mar 21, 2020·Lancet·Puja MehtaUNKNOWN HLH Across Speciality Collaboration, UK
Mar 29, 2020·The Journal of Clinical Investigation·Savannah F Pedersen, Ya-Chi Ho
Mar 29, 2020·The Journal of Clinical Investigation·Guang ChenQin Ning
Apr 16, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sufang TianShu-Yuan Xiao
Apr 18, 2020·Translational Research : the Journal of Laboratory and Clinical Medicine·Cynthia MagroJeffrey Laurence
Apr 25, 2020·Intensive Care Medicine·Marie-Christine CopinUNKNOWN Lille COVID-19 ICU and Anatomopathology Group
Apr 29, 2020·The European Respiratory Journal·Jordi RelloRicardo Serrano
May 20, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Raef FadelUNKNOWN Henry Ford COVID-19 Management Task Force

❮ Previous
Next ❯

Citations

Aug 5, 2020·AAPS PharmSciTech·Humzah JamshaidFakhar Ud Din
Aug 31, 2020·Experimental Hematology & Oncology·José Luis PiñanaUNKNOWN Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH)
Jul 28, 2020·Journal of Clinical Medicine·Chrysi KoliakiNikolaos Tentolouris
Oct 22, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Enric MonrealUNKNOWN COVID-HRC group
Dec 1, 2020·Expert Review of Respiratory Medicine·Qian ChenTao Wang
Jan 7, 2021·Cardiovascular Drugs and Therapy·Xiang PengJinwei Tian
Jan 26, 2021·Indian Journal of Endocrinology and Metabolism·Mahendra K GargSanjeev Misra
Mar 12, 2021·Expert Review of Clinical Pharmacology·Sayeeda RahmanFrank Kunik
Dec 29, 2020·The Journal of Infection·O Gandini, C Lubrano
May 15, 2021·Archivos de bronconeumología·Mina GagaLykourgos Kolilekas
Jul 13, 2021·Indian Journal of Anaesthesia·Vyshnavi RenganathanRamachandran Gopinath
Jun 16, 2021·Pulmonary Pharmacology & Therapeutics·Elena VillamañánRodolfo Álvarez-Sala
Aug 14, 2021·Indian Journal of Endocrinology and Metabolism·Bharat KumarSanjeev Misra
Oct 19, 2021·Saudi Journal of Biological Sciences·Muhammad Farhat UllahM Y Malik
Jul 14, 2021·Experimental Biology and Medicine·Frans A KuypersClaudia R Morris
Jan 14, 2022·Communications Biology·Christopher J NeufeldtRalf Bartenschlager

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Intensive Care Medicine
Nicolas MongardonCOVADIS study group investigators
Critical Care : the Official Journal of the Critical Care Forum
Luciano GattinoniSandra Rossi
Journal of Clinical Anesthesia
Manuel TaboadaPeter G Atanassoff
European Journal of Case Reports in Internal Medicine
Yvon RuchFrançois Danion
© 2022 Meta ULC. All rights reserved