Can structure predict function in the human brain?

NeuroImage
Christopher J HoneyOlaf Sporns

Abstract

Over the past decade, scientific interest in the properties of large-scale spontaneous neural dynamics has intensified. Concurrently, novel technologies have been developed for characterizing the connective anatomy of intra-regional circuits and inter-regional fiber pathways. It will soon be possible to build computational models that incorporate these newly detailed structural network measurements to make predictions of neural dynamics at multiple scales. Here, we review the practicality and the value of these efforts, while at the same time considering in which cases and to what extent structure does determine neural function. Studies of the healthy brain, of neural development, and of pathology all yield examples of direct correspondences between structural linkage and dynamical correlation. Theoretical arguments further support the notion that brain network topology and spatial embedding should strongly influence network dynamics. Although future models will need to be tested more quantitatively and against a wider range of empirical neurodynamic features, our present large-scale models can already predict the macroscopic pattern of dynamic correlation across the brain. We conclude that as neuroscience grapples with dataset...Continue Reading

References

Feb 1, 1978·The Journal of Comparative Neurology·D H HubelM P Stryker
Jan 1, 1991·Cerebral Cortex·D J Felleman, D C Van Essen
Jan 1, 1990·Neuropsychologia·P R Huttenlocher
Sep 22, 1988·Nature·S Zeki, S Shipp
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·R MalachA Grinvald
Apr 1, 1997·Brain : a Journal of Neurology·V B Mountcastle
Jul 28, 1997·The Journal of Comparative Neurology·B Pakkenberg, H J Gundersen
Jul 2, 1998·Brain : a Journal of Neurology·M M Mesulam
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·G TononiG M Edelman
Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·M P YoungJ W Scannell
Feb 13, 2001·Journal of Physiology, Paris·W J Freeman
Feb 24, 2001·Proceedings of the National Academy of Sciences of the United States of America·M E RaichleG L Shulman
Feb 9, 2002·Human Brain Mapping·Michael Breakspear
Apr 24, 2002·NeuroImage·Martin A KochMargret Hund-Georgiadis
May 4, 2002·Neuron·Dmitri B ChklovskiiCharles F Stevens
Dec 6, 2002·Cerebral Cortex·Alex M Thomson, A Peter Bannister
Dec 31, 2002·Proceedings of the National Academy of Sciences of the United States of America·Michael D GreiciusVinod Menon
Sep 27, 1955·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A M UTTLEY
Mar 30, 2004·Trends in Neurosciences·György BuzsákiXiao-Jing Wang
Apr 16, 2004·Biological cybernetics·Naoki Masuda, Kazuyuki Aihara
Apr 27, 2004·Human Brain Mapping·Cornelis Jan Stam, Eveline Astrid de Bruin
May 19, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nitin GogtayPaul M Thompson
May 29, 2004·Neural Computation·Nils Bertschinger, Thomas Natschläger
Jun 29, 2004·Biological cybernetics·Marcus Kaiser, Claus C Hilgetag
Jul 21, 2004·Neuron·Armen StepanyantsDmitri B Chklovskii
Aug 21, 2004·Neuroinformatics·Olaf Sporns, Jonathan D Zwi
Sep 8, 2004·Trends in Cognitive Sciences·Olaf SpornsClaus C Hilgetag
Nov 24, 2004·Nature Neuroscience·Astrid A PrinzEve Marder
Jun 2, 2005·Trends in Neurosciences·Shaul Hestrin, Mario Galarreta
Jun 7, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jonathan C Horton, Daniel L Adams
Aug 10, 2005·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Michael Breakspear, Cornelis J Stam
Oct 5, 2005·PLoS Computational Biology·Olaf SpornsRolf Kötter
Aug 1, 2006·Schizophrenia Research·Sifis MicheloyannisMichael Zervakis
Sep 2, 2006·Proceedings of the National Academy of Sciences of the United States of America·J S DamoiseauxC F Beckmann
Sep 22, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Elisabeth RounisRichard S J Frackowiak
Nov 3, 2006·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Danielle Smith Bassett, Ed Bullmore
Nov 23, 2006·Nature Neuroscience·Doug RubinoNicholas G Hatsopoulos
Dec 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Danielle S BassettEdward Bullmore

❮ Previous
Next ❯

Citations

Dec 8, 2010·Magma·Ewald Moser, Jean-Philippe Ranjeva
Apr 9, 2013·Trends in Neurosciences·Gustavo DecoAnthony R McIntosh
Jan 17, 2013·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Donatello ArienzoJamie D Feusner
Oct 20, 2010·Proceedings of the National Academy of Sciences of the United States of America·Benjamin MorillonAnne-Lise Giraud
Nov 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·David J HawellekAndreas K Engel
Jan 1, 2011·Brain Connectivity·Saad Jbabdi, Heidi Johansen-Berg
Jan 1, 2011·Brain Connectivity·Scott J Peltier, Yash Shah
Oct 7, 2011·Brain : a Journal of Neurology·Zhiqiang ZhangGuangming Lu
Jun 16, 2011·PLoS Computational Biology·Bratislav MišićAnthony R McIntosh
Aug 24, 2012·PLoS Computational Biology·Willem de HaanCornelis J Stam
Jan 10, 2013·PLoS Computational Biology·Anne L WheelerPaul W Frankland
Jan 26, 2013·PloS One·Kathleen VincentJean-Philippe Thivierge
Mar 7, 2014·PloS One·Maarten J VaessenWalter H Backes
Jan 21, 2014·Brain Connectivity·James A Henderson, Peter A Robinson
Feb 13, 2014·Brain : a Journal of Neurology·Guillaume HerbetHugues Duffau
Sep 3, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David PapoJavier M Buldú
Sep 3, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Leonardo L Gollo, Michael Breakspear
Jan 23, 2014·ELife·Rishidev ChaudhuriXiao-Jing Wang
Jan 17, 2016·Developmental Cognitive Neuroscience·Roberta A Schriber, Amanda E Guyer
Aug 24, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ryouhei Ishii, Leonides Canuet
May 1, 2013·Neuroscience and Biobehavioral Reviews·Ilana J Bennett, Bart Rypma
Jan 17, 2016·Social Cognitive and Affective Neuroscience·Daniel Joel ShawTomáš Paus
Jul 28, 2016·Biological Psychiatry : Cognitive Neuroscience and Neuroimaging·Henry W Chase, Mary L Phillips
May 15, 2012·Neuroscience Letters·Melissa A FarmerA Vania Apkarian
Aug 23, 2011·Journal of Physiology, Paris·Pablo Maturana, Bénédicte Batrancourt
May 21, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Liping WangJin-Ye Wang
Apr 19, 2011·Trends in Cognitive Sciences·Danielle S Bassett, Michael S Gazzaniga

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Christopher J HoneyP Hagmann
Proceedings of the National Academy of Sciences of the United States of America
Christopher J HoneyOlaf Sporns
© 2021 Meta ULC. All rights reserved