PMID: 8605086Mar 1, 1996Paper

Can supplementary dietary fibre suppress breast cancer growth?

British Journal of Cancer
B A Stoll

Abstract

Case-control studies in diverse populations around the world have reported a lower risk of breast cancer in association with higher intake of dietary fibre and complex carbohydrates. Although this has not been confirmed in prospective studies in the USA, the observations have prompted the hypothesis that prolonged use of dietary fibre supplements might reduce breast cancer risk in high-incidence populations. Several possible mechanisms of action have been suggested, all involving a reduction of bioactive oestrogen levels in the blood. The various mechanisms are not necessarily mutually exclusive. First, a high-fibre diet might reduce circulating oestrogen levels by reducing the enterohepatic recirculation of oestrogen. Second, many plants and vegetables contain isoflavones and lignans capable of conversion in the bowel into weak oestrogens that may compete with oestradiol for target binding-sites. Third, a high-fibre diet is less often associated with obesity, which tends to increase availability of the biologically active 16-alpha metabolites of oestrone. Fourth, a high-fibre diet usually has a lower content of fat and a higher content of antioxidant vitamins, which may protect against breast cancer risk. Finally, diets rich i...Continue Reading

Citations

Oct 29, 1997·Breast Cancer Research and Treatment·G N RaoR A Herbert
May 28, 2009·The Breast Journal·Keith I BlockJacob Shoham
Feb 16, 2010·Nutrition and Cancer·Mark Messina, Leena Hilakivi-Clarke
Jun 22, 2012·International Journal of Food Sciences and Nutrition·Leo StevensonJenny Walton
Sep 30, 2010·Metabolic Syndrome and Related Disorders·Mehrshad AbbasiManouchehr Nakhjavani

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