Can susceptibility to an antimicrobial be restored by halting its use? The case of streptomycin versus Enterobacteriaceae

The Journal of Antimicrobial Chemotherapy
Y F ChiewD M Livermore

Abstract

To test the widespread view that resistance disappears in the absence of antimicrobial use, we tested streptomycin against 477 Enterobacteriaceae from the Royal London Hospital. Twenty per cent proved resistant although streptomycin is little used at the hospital and streptomycin resistance in gram-negative bacteria is caused by mechanisms that do not compromise the drugs that are used. Up to 70% of the observed resistance was associated with cross-resistance to spectinomycin and the presence of ant(3")-Ia, an integron-associated gene carried in Tn21-type transposons. This genetic organization may have conserved streptomycin resistance in the absence of direct selection pressure.

Citations

Jul 4, 2006·Indian Journal of Pediatrics·Aditya H Gaur, B Keith English
Nov 30, 2000·Current Infectious Disease Reports·D E LowG D Wright
Mar 17, 2004·Diagnostic Microbiology and Infectious Disease·M M NaviaJ Vila
Mar 29, 2003·Diagnostic Microbiology and Infectious Disease·G J MazzolaJ A Poupard
Oct 26, 2000·Current Opinion in Microbiology·D M Livermore, M N Dudley
Oct 6, 1999·Current Opinion in Microbiology·D Guillemot
Mar 24, 2004·Nature Reviews. Microbiology·David Livermore
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·I Phillips
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D E Low
Jul 20, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·D GuillemotUNKNOWN French Working Party to Promote Research to Control Bacterial Resistance
May 4, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne O Summers
Jan 8, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David M Livermore
Apr 10, 2003·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson, Louis B Rice
Jun 1, 1999·The Journal of Antimicrobial Chemotherapy·I M Gould
Nov 11, 2009·The Journal of Antimicrobial Chemotherapy·M SundqvistG Kahlmeter
Dec 17, 2009·The Journal of Antimicrobial Chemotherapy·Virve I Enne
Jun 28, 2011·The Journal of Antimicrobial Chemotherapy·Judith A TroughtonRonan McMullan
May 19, 2000·Antimicrobial Agents and Chemotherapy·D MazelJ Davies
Apr 18, 2002·Antimicrobial Agents and Chemotherapy·Peter SanderErik C Böttger
Dec 2, 2005·Emerging Infectious Diseases·Patrice Courvalin
Apr 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Sobhan NandiAnne O Summers
Oct 17, 2013·Enfermedades infecciosas y microbiología clínica·Santiago GrauLuis Martínez-Martínez
Jun 5, 2004·Journal of Vascular and Interventional Radiology : JVIR·J Mark RyanTony P Smith
Nov 13, 2002·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Keryn ChristiansenO Cars
Oct 27, 2007·The Lancet Infectious Diseases·Jarold L CosbyChristopher C Butler
Dec 9, 2004·Pharmacotherapy·John A Bosso
Jun 28, 2005·The Lancet Infectious Diseases·David M Livermore
Jun 5, 2004·Clinics in Laboratory Medicine·Fernanda SilveiraDavid L Paterson
Oct 7, 2015·Frontiers in Microbiology·Lindsay M D JacksonGideon M Wolfaardt
May 20, 2014·Upsala Journal of Medical Sciences·Martin Sundqvist
Feb 5, 2004·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·P Severino, V D Magalhães
Feb 18, 2005·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·M GrapeL Sundström
Apr 5, 2013·Clinical Microbiology Reviews·Alejandro BeceiroGermán Bou
Oct 24, 2019·Veterinary World·Djanette BarourNadji Boulebda
Jan 6, 2000·FEMS Microbiology Letters·P A WhiteW D Rawlinson
Jan 24, 2012·The Veterinary Record·A FlamentD Marlier

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases (ASM)

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Allergy & Infectious Diseases

Allergies result from the hyperreactivity of the immune system to some environmental substance and can be life-threatening. Infectious diseases are caused by organisms including bacteria, viruses, fungi and parasites. They can be transmitted different ways, such as person-to-person. Here is the latest research on allergy and infectious diseases.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
A DigranesJ Sander
European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
M G van KraaijM Rozenberg-Arska
The New England Journal of Medicine
Jaime Martinez-UrtazaAngelo DePaola
© 2022 Meta ULC. All rights reserved