Can Synovial Pathobiology Integrate with Current Clinical and Imaging Prediction Models to Achieve Personalized Health Care in Rheumatoid Arthritis?

Frontiers in Medicine
Frances Claire HumbyCostantino Pitzalis

Abstract

Although great progress has been made in the past decade toward understanding the pathogenesis of rheumatoid arthritis (RA), clinicians remain some distance from a goal of personalized health care. The capacity to diagnose RA early, predict prognosis, and moreover predict response to biologic therapies has been a research focus for many years. How currently available clinical prediction models can facilitate such goals is reviewed in this article. In addition, the role of current imaging techniques in this regard is also discussed. Finally, the authors review the current literature regarding synovial biomarkers and consider whether integration of synovial pathobiology into clinical prediction algorithms may enhance their predictive value.

References

Feb 13, 2002·Arthritis and Rheumatism·Henk VisserJohanna M W Hazes
Jan 15, 2004·Annals of the Rheumatic Diseases·F C BreedveldR N Maini
Jun 18, 2004·The New England Journal of Medicine·Jonathan C W EdwardsTim Shaw
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Nov 17, 2005·Rheumatic Diseases Clinics of North America·Helen I KeenPhilip G Conaghan
Mar 2, 2006·Arthritis Research & Therapy·Johan LindbergJoakim Lundeberg
Mar 2, 2006·Arthritis and Rheumatism·Josef S SmolenUNKNOWN Active-Controlled Study of Patients Receiving Infliximab for the Treatment of Rheumatoid Arthritis of Early Onset (ASPIRE) S
Jul 5, 2006·Arthritis Research & Therapy·Thierry LequerréJean-Philippe Salier
Jun 3, 2008·Arthritis and Rheumatism·Jonathan C W Edwards, Maria J Leandro
Jun 3, 2008·Arthritis and Rheumatism·Rogier M ThurlingsPaul P Tak
Oct 14, 2009·International Journal of Immunopathology and Pharmacology·F LicastroE Porcellini

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Citations

Feb 29, 2020·Journal of Leukocyte Biology·Federica MaioneAnnalisa Chiocchetti
Dec 5, 2018·Arthritis Research & Therapy·Aurélie NajmUNKNOWN EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group
Apr 4, 2021·International Journal of Molecular Sciences·Seyedeh Maryam HosseinikhahMagali Cucchiarini

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Methods Mentioned

BETA
biopsy
ESR
biopsies
transcription profiling
dissect

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