Can the aggregation be a new approach for understanding the mechanism of Traditional Chinese Medicine?

Journal of Ethnopharmacology
Yan ZhuangXiaojie Xu

Abstract

"Frequent hitter" phenomenon emerged in the high-throughput screening; one of the most common mechanisms behind artifactual inhibition is that some organic molecules formed large colloid-like aggregates which are able to sequester and thereby inhibit enzymes. To investigate the situation in Traditional Chinese Medicine (TCM), 60 medicinal herbs and 24 Chinese herbal formulae were detected by dynamic light scattering (DLS), and aggregates were observed in all the 84 solution mixtures. The aggregates of two Chinese herbal formulae, 'Xue-Fu-Zhu-Yu Tang' (XF) and 'Jing-Guan Tang' (JG), were not only able to survive in the gastro-intestinal environment, but also had the ability to pass through the monolayer of the Caco-2 cell. The activities of XF and JG against three cardiovascular targets were also aggregates-related. Based on these findings, a new possible mechanism of the action of Chinese medicine was proposed.

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Citations

Jul 26, 2011·Evidence-based Complementary and Alternative Medicine : ECAM·Si-Yuan PanKam-Ming Ko
Jul 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Gong WangWensheng Pang
Mar 14, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Xixi CaiShaoyun Wang
Jul 25, 2019·Journal of Agricultural and Food Chemistry·Jianwu ZhouQiang Wang

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