PMID: 2492785Mar 1, 1989Paper

Can the hypotriglyceridemic effect of fish oil concentrate be sustained?

Annals of Internal Medicine
G SchectmanA Kissebah

Abstract

To determine whether high doses of fish oil concentrate followed by low-dose maintenance therapy can sustain the initial plasma triglyceride reductions. Before-and-after trial with 3-month treatment periods. Outpatient lipid clinic at a university medical center. Sixteen patients with hypertriglyceridemia recruited from the General Internal Medicine Clinics. Five had concomitant hypercholesterolemia (type IIb). Fish oil supplementation at two doses. After basal measurements, 9.8 g/d omega-3 fatty acids were provided for study months 1 to 3, and 3.9 g/d were provided for study months 4 to 6. Blood was drawn monthly and plasma was analyzed for levels of triglycerides, low-density-lipoprotein (LDL) cholesterol and apolipoprotein B, high-density-lipoprotein (HDL) cholesterol and apolipoprotein A1, and glucose and glycohemoglobin. During therapy with the higher dose, mean plasma triglyceride levels were reduced from 3.65 +/- 0.35 mmol/L at baseline to 1.85 +/- 0.20 mmol/L at 1 month, but increased by 30% to 2.40 +/- 0.30 mmol/L by the third month of therapy (P less than 0.05): this increase could not be explained by changes in body weight or compliance. Plasma triglyceride levels continued to increase with low-dose therapy and remai...Continue Reading

Citations

Jan 1, 1992·Journal of the American College of Cardiology·D H Israel, R Gorlin
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H J Bilo, R O Gans
Aug 19, 1989·Lancet
Sep 20, 1989·Sygeplejersken·J Dyerberg
Dec 1, 1990·Baillière's Clinical Endocrinology and Metabolism·T A Sanders
Jun 1, 1991·Journal of the American College of Nutrition·W S HarrisC A Dujovne
Oct 1, 1990·Australian and New Zealand Journal of Medicine·L A SimonsS Balasubramaniam
Jul 17, 2013·International Journal of Cardiology·Angela Pirillo, Alberico Luigi Catapano
Jul 15, 2000·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·G Bulliyya
Jan 18, 2013·Food & Function·Tiffany NicholsonMohammed H Moghadasian
Jul 1, 1994·Scandinavian Journal of Clinical and Laboratory Investigation·J EritslandP A Torjesen
Sep 1, 1992·The Annals of Pharmacotherapy·K GeurianC W Weart
Oct 1, 1991·Postgraduate Medicine·W L Peters

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