Can the Impact of Topiramate on Memory Processes be Related to Its 'Antialcoholic Activity'?-A Preclinical Study

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Ewa ZwierzyńskaBogusława Pietrzak

Abstract

Topiramate causes the inhibition of alcohol consumption in addicts but the mechanism of this action has not been fully understood yet. Nowadays, it seems that memory may have a role in the development of dependence. In this study, the impact of topiramate and ethanol on the bioelectric activity of the brain in rabbits and on spatial memory in rats was evaluated. The aim of the study was to assess the effect of co-administration of topiramate and ethanol on bioelectric activity of the rabbits' brain and on spatial memory in rats. Topiramate decreased ethanol-induced changes in all studied brain structures and improved memory and learning processes. A pharmaco-electroencephalography study was used to examine the effect of topiramate (25 mg/kg/day) co-administered for 6 weeks with ethanol on the bioelectric activity of the rabbits' brain. The influence of the drug was also assessed in first and second weeks of the abstinence period. Spatial memory was evaluated in rats using Morris water maze task. Topiramate (60 mg/kg/day) was administered with the ethanol for 3 weeks and for 2 weeks in the abstinence. After 6 weeks of topiramate and ethanol administration, the drug decreased ethanol-induced changes in the midbrain reticular form...Continue Reading

References

Dec 1, 1954·The Journal of Comparative Neurology·C H SAWYERJ D GREEN
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·M A RigoulotA Nehlig
Feb 24, 2006·Nature Neuroscience·Sabrina DianoTamas L Horvath
Aug 4, 2006·Experimental Neurology·Mi-Ra NohBaik-Lin Eun
Dec 6, 2006·Synapse·Shaun A NguyenLawrence D Middaugh
Jun 6, 2007·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Justin M FarookSusan Barron
Jun 22, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert E ClarkLarry R Squire
Oct 11, 2007·JAMA : the Journal of the American Medical Association·Bankole A JohnsonUNKNOWN Topiramate for Alcoholism Study Group
Jan 25, 2008·Alcoholism, Clinical and Experimental Research·Robert MirandaJohn McGeary
May 17, 2008·Alcoholism, Clinical and Experimental Research·Gerardo FlórezJulio Bobes
Nov 17, 2009·Journal of Clinical Psychopharmacology·Gabriel RubioJorge Manzanares
Mar 16, 2011·BMC Psychiatry·Thomas PaparrigopoulosIoannis Liappas
Jun 16, 2011·The Journal of International Medical Research·L ZhangZ-X Zhao
Jan 9, 2014·Pharmacological Reports : PR·Bogusława PietrzakJakub Wojcieszak
Feb 15, 2014·The American Journal of Psychiatry·Henry R KranzlerKyle M Kampman
Aug 6, 2014·Alcoholism, Clinical and Experimental Research·Steven L BatkiEllen Herbst
Oct 3, 2014·Journal of Clinical Psychopharmacology·Giovanni MartinottiLuigi Janiri
Nov 27, 2014·Journal of Clinical Psychopharmacology·Clifford M KnappCourtney Richambault
Nov 12, 2016·The Indian Journal of Medical Research·Sudhir Chandra SarangiYogendra Kumar Gupta
Feb 19, 2017·Neurology·Britta WandschneiderMatthias J Koepp
Mar 14, 2017·Experimental and Clinical Psychopharmacology·Décio D Junqueira-AyresElaine C Gavioli

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

Attention Disorders

Attention is involved in all cognitive activities, and attention disorders are reported in patients with various neurological diseases. Here are the latest discoveries pertaining to attention disorders.

Related Papers

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Agata Krupa-BurtnikBogusława Pietrzak
The American Journal of Drug and Alcohol Abuse
Ewa ZwierzyńskaBogusława Pietrzak
Polish Journal of Pharmacology and Pharmacy
Elzbieta CzarneckaB Pietkiewicz
© 2022 Meta ULC. All rights reserved