Can the neutrophil/lymphocyte ratio (NLR) have a role in the diagnosis of coronavirus 2019 disease (COVID-19)?

Revista da Associação Médica Brasileira
Ahmet NalbantHakan Cinemre

Abstract

OBJECTIVE The present study aimed to investigate the role of neutrophil/lymphocyte ratio (NLR), an inflammation marker, complete blood count, and biochemical parameters in the diagnosis of COVID-19. METHODS A total of 80 patients who had been hospitalized in the internal medicine clinic were enrolled in the study. The cases were allocated into two groups, i.e., COVID (+) and (-), based on real-time reverse transcription-polymerase chain reaction. The demographic, clinical, and laboratory [NLR, platelet/lymphocyte ratio (PLR), complete blood count, biochemistry, and serology] data of the patients were retrospectively obtained from the hospital data management system. RESULTS NLR and fever levels were found to be higher in COVID-19 (+) cases (P=0.021, P=0.001, respectively). There was no difference between males and females with regard to COVID-19 positivity (P=0.527). Total bilirubin levels were found to be lower in COVID-19 (+) cases (P=0.040). When the ROC analysis was carried out for NLR in COVID-19 (+) cases, the AUC value was found to be 0.660 (P=0.021), sensitivity as 69.01 %, specificity as 65.40 %, LR+: 1.98 and LR- : 0.48, PPV: 80.43, and NPV: 50.00, when the NLR was ≥2.4. The risk of COVID-19 was found to be 20.3-fold ...Continue Reading

References

Oct 19, 2012·The New England Journal of Medicine·Ali M ZakiRon A M Fouchier
Jun 20, 2015·Mediators of Inflammation·J R ThieleS U Eisenhardt
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Mar 28, 2020·Journal of Gastroenterology and Hepatology·Sunny H WongJoseph Jy Sung
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May 16, 2020·Critical Care : the Official Journal of the Critical Care Forum·Yuan YuYou Shang

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Citations

Nov 18, 2020·Critical Care : the Official Journal of the Critical Care Forum·Xiaoming LiFeihu Zhou
Apr 13, 2021·Expert Review of Molecular Diagnostics·Ahmed Abdelaal Ahmed Mahmoud M AlkhatipMohamed Helmy
Jul 15, 2021·Revista da Associação Médica Brasileira·Gulali Aktas
Jul 15, 2021·Revista da Associação Médica Brasileira·Cihan BedelHamit Hakan Armağan
Jun 18, 2021·International Journal of Clinical Practice·Ahmet NalbantErtuğrul Güçlü

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