Can the Presence of Crystalluria Predict Stone Formation in Patients with Cystinuria?

Journal of Endourology
Kathie A WongKay Thomas

Abstract

To determine the feasibility of crystalluria as a biomarker for stone disease in patients with cystinuria. All patients attending a multidisciplinary cystinuria clinic provided early morning urine (EMU) and clinic urine (CU) samples for crystal measurement over a 2-year period (August 1, 2010, to July 31, 2012). Association between presence of crystals, presence of stone(s), and new stone growth (NSG) was determined using the chi-square test. Crystal numbers in EMU and CU were compared in patients with stones/NSG and no stones/stable disease using the Mann-Whitney U test. There was a statistically significant difference between the presence of crystalluria and presence of stones for CU (chi-square test = 5.86, df = 1, p = 0.02) but not EMU (chi-square test = 1.92, df = 1, p = 0.17) and between the presence of crystalluria and NSG for CU (chi-square test = 8.10, df = 1, p = 0.004) but not EMU (chi-square test = 1.32, df = 1, p = 0.25). Patients with stones and NSG have higher levels of crystalluria in CU than patients with no stones or stable disease (stones, median = 41, interquartile range [IQR] = 600 vs median = 0, IQR = 21, p = 0.01; NSG, median = 49, IQR = 525 vs median = 0, IQR = 40, p = 0.01). The presence of crystalluria...Continue Reading

References

Dec 2, 1965·The New England Journal of Medicine·L E RosenbergJ M Holland
May 1, 1983·The Journal of Urology·C Y Pak, C J Fuller
Jan 1, 1995·Urological Research·A LindellH G Tiselius
Sep 20, 2002·Journal of the American Society of Nephrology : JASN·Luca Dello StrologoGianfranco Rizzoni
Mar 1, 1965·The Journal of Clinical Investigation·S O THIERL E ROSENBERG
Apr 21, 2005·Kidney International·Michel DaudonPaul Jungers
Feb 28, 2006·Kidney International·D S GoldfarbJ R Asplin
Nov 9, 2007·Journal of Analytical Toxicology·Janine D CookDonna M Bush
Mar 17, 2011·Clinical Chemistry·Karen van HoeveElena Levtchenko
Mar 26, 2014·Nature Reviews. Urology·Kay ThomasAngela Doherty
Jun 9, 2014·Urology·Toru KannoHitoshi Yamada

❮ Previous
Next ❯

Citations

Jun 9, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Vincent CastiglioneRomy Gadisseur
Nov 15, 2017·Nature Reviews. Urology·Matthew Bultitude, Kay Thomas
Sep 13, 2020·Kidney International·Aude ServaisUNKNOWN Metabolic Nephropathy Workgroup of the European Reference Network for Rare Kidney Diseases (ERKNet) and eUROGEN
Apr 2, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Aniello PrimianoJacopo Gervasoni
Nov 24, 2021·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Viola D'AmbrosioPietro Manuel Ferraro

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
imaging techniques

Software Mentioned

SPSS
MedCalc

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.