Can the use of growth hormone reduce the postoperative fatigue syndrome?

World Journal of Surgery
R Vara-ThorbeckM García-Carriazo

Abstract

Convalescence after surgery is characterized by a period of fatigue (POF). If we assume that the POF syndrome has a multifactorial etiology, it is clear that the aim of therapeutic measures should be to reduce the response to surgical stress. The purpose of the present study was to determine if administering exogenous human growth hormone (hGH) can prevent the development or reduce the duration of the POF. We carried out a placebo-controlled randomized double-blind trial with 48 patients after elective cholecystectomy (placebo, or control group, n = 26; hGH-treated group, n = 22). Eligibility criteria were strict so as to introduce as few variables as possible. The results obtained in the study show that for moderate surgical injury (cholecystectomy in metabolically healthy subjects) the administering of low doses of hGH (8 IU/day) minimized the POF syndrome (Christensen score). Furthermore, a positive nitrogen balance was achieved in the hGH-treated group during the postoperative period from the first 24 hours onward. This finding correlates with the significant increase in serum levels of hGH (p < 0.05) and insulin-like growth factor 1 (IGF-1) (p < 0.001). On the other hand, anthropometric measurements in the hGH-treated grou...Continue Reading

Citations

Jul 21, 2007·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Yanqing GuoZhaohui Tang
Aug 24, 1999·Current Opinion in Clinical Nutrition and Metabolic Care·D W Wilmore
Aug 3, 2002·The British Journal of Surgery·G J Rubin, M Hotopf
Oct 3, 2012·Conservation Biology : the Journal of the Society for Conservation Biology·Jamie R WoodAlan Cooper
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·A J CleareJ P Miell
Apr 18, 2003·Endocrine Reviews·Anthony J Cleare

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