Can the use of HEPA cleaners in homes of asthmatic children and adolescents sensitized to cat and dog allergens decrease bronchial hyperresponsiveness and allergen contents in solid dust?

International Archives of Allergy and Immunology
Claudia SulserSusanne Lau

Abstract

Exposure and sensitization to pet allergens are associated with allergic asthma in children. Conflicting data have emerged regarding the potential benefit of air cleaners with respect to a reduction of indoor pet allergens and bronchial hyperresponsiveness (BHR). In a randomized controlled trial 36 asthmatic children with sensitization to cat and/or dog and significant exposure to cat and/or dog allergen (Fel d 1 and/or Can f 1 >500 ng/g of carpet dust) were included in order to study the effect of high-efficiency particulate arresting (HEPA) air cleaners placed in the living room and bedroom compared with the effect of sham air cleaners. Patients were allocated to two groups: group 1 exposed to active filters and group 2 exposed to sham filters. At month 0, after 6 months and after 12 months, pulmonary function testing and cold air challenge were performed, serum eosinophil cationic protein (ECP) and specific IgE to seven aeroallergens were determined, and carpet dust samples and filters were collected. Major pet allergen concentrations (Fel d 1, Can f 1) were determined in filters and bulk dust samples. Thirty patients completed the study. After 6 and 12 months, there was no significant change in delta FEV(1) after cold air c...Continue Reading

Citations

Oct 10, 2009·Current Allergy and Asthma Reports·Thomas A LupoliJay M Portnoy
Feb 4, 2014·Current Allergy and Asthma Reports·Lakiea S Wright, Wanda Phipatanakul
Jan 18, 2014·Air Quality, Atmosphere, & Health·Stuart BattermanWilma Brakefield-Caldwell
Apr 4, 2012·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jay PortnoyJohn Oppenheimer
Apr 9, 2010·Veterinary Dermatology·Daniel O Morris
Feb 13, 2013·Indoor Air·W J Fisk
Nov 17, 2009·The Journal of Allergy and Clinical Immunology·James L SublettUNKNOWN American Academy of Allergy, Asthma & Immunology Indoor Allergen Committee
Jul 8, 2016·Indoor Air·D Haaland, J A Siegel
Nov 2, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Hye-Kyung ParkKari C Nadeau
Feb 6, 2017·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Meredith A Dilley, Wanda Phipatanakul
Dec 16, 2016·PloS One·Sangita VyasDean Spears
Mar 30, 2013·Clinical Pediatrics·James R RobertsJoel Forman
Sep 30, 2010·Yonsei Medical Journal·Santosh Rani AgrawalJung-Won Park
Sep 29, 2019·International Journal of Environmental Research and Public Health·Mary Clare HanoWayne E Cascio
Jun 18, 2020·Current Allergy and Asthma Reports·Nicole Akar-Ghibril, Wanda Phipatanakul
May 16, 2020·Current Allergy and Asthma Reports·Alina Gherasim, Frédéric de Blay
Dec 28, 2019·Allergologia et immunopathologia·Ziemowit StrzelczykAgnieszka Krauze
Oct 8, 2020·The World Allergy Organization Journal·Todor A PopovIgnacio J Ansotegui
May 12, 2018·The Journal of Allergy and Clinical Immunology. in Practice·Ahmad Salaheddine NajaWanda Phipatanakul
Jan 10, 2018·The Journal of Allergy and Clinical Immunology. in Practice·Sharon K Ahluwalia, Elizabeth C Matsui
Jul 12, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Clare S MurrayW Gerald Teague
Mar 19, 2020·International Archives of Allergy and Immunology·Frank E van BovenRoy Gerth van Wijk
Dec 13, 2016·Pediatrics·Elizabeth C MatsuiUNKNOWN COUNCIL ON ENVIRONMENTAL HEALTH

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